Apple Inc.

Amgen Inc.

Minute Key Inc.

The Hillman Group, Inc.

Daiichi Sankyo Europe Gmbh

Daiichi Sankyo Company, Limited

U3 Pharma Gmbh

Element Extreme LLC

Other

Creative Technology Corporation

Kinki University

Minute Key Holdings Inc.

Daniel Freeman

Derek Boyd Barrentine

Robert Radinsky

Ari Freeman

Anthony Michael Fadell

Brian Quentin Huppi

Thore Hettmann

Todd Juan

Sabine Blum

Matthias Schneider

Xiaoping Jin

Robert Allen Beckman

Renee Jeanne Mendell-Harary

Mike Rothe

Gary Elliott

Anthony M Fadell

Jilin Sun

Kenneth H Jung

Derek Barrentine

Brian Huppi

Eric Borges

Martin Treder

Skip Thomas Orvis

Susanne Hartmann

Kazuhiko Nakagawa

Howard N Egan

Ralph Niven

Kimio Yonesaka

Girault Jones

Andrei Veltchev

The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as low.

Nucleic acid biomarker and use thereof

Methods and systems in which a portable electronic device can be voice activated are disclosed. The portable electronic device can be a multi-function electronic device. The voice activation can be robust and context sensitive. The voice activation can also be utilized without any preparatory user action with respect to the portable electronic device. The portable electronic device can also interact with a media system.

Method and system for operating a multi-function portable electronic device using voice-activation

Described herein are materials and methods for treating subjects having a HER-3 associated disease, by administering a first agent that binds to HER-3, in combination with a second agent that binds and/or inhibits another member of the HER family. The first and the second agent may be a biologic, such as an antigen-binding protein, or a small molecular tyrosine kinase inhibitor, for example.

Material and methods for treating or preventing HER-3 associated diseases

The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low. The invention is also directed to methods of performing an ELISA, including sequential steps of contacting a solid surface with a plurality of solutions each comprising in turn a capture antibody, a blocking agent, a sample suspected of containing an analyte, a detection antibody and an enzyme conjugate, in which the solid surface is subjected to a wash process after each sequential step.

Protein biomarker and uses thereof

A key-duplicating system comprises a network that includes a multiplicity of kiosks at a multiplicity of different locations, each of the kiosks having a customer interface and a processor coupled to the customer interface. A remote central server coupled to the kiosks is adapted to receive, from the kiosks, information identifying master keys to be duplicated. A key analysis module uses the information identifying master keys to be duplicated to derive information required to produce duplicates of the identified master keys, and a key duplicating module uses that information to produce duplicates of said identified master keys.

Key duplication system

Method and system for operating a multifunction portable electronic device using voice-activation

The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors.

K-ras mutations and anti-EGFr antibody therapy

A metered smoking apparatus includes a burnable media including indicia that visually represent a plurality of smokable units of a smokable substance or an active ingredient thereof, each of the smokable units corresponding to a same predetermined quantity of the smokable substance or the active ingredient thereof, and when the smokable substance is rolled within the burnable media, the burnable media is configured such that the indicia are sequentially burned in a burn line direction that is a direction in which a burn line burns when the metered smoking apparatus is smoked, to thereby indicate consumption of the predetermined quantity on a unit-by-unit basis.

Metered smoking apparatus

Methods and systems in which a portable electronic device can be voice to activated are disclosed. The portable electronic device can be a multi-function electronic device. The voice activation can be robust and context sensitive. The voice activation can also be utilized without any preparatory user action with respect to the portable electronic device. The portable electronic device can also interact with a media system.

An automatic key duplicating machine is disclosed. A master key identification module includes at least one key blade cross-section detector with a plurality of sliding elements, the master key identification module being configured to determine a key type for a master key based at least in part on engagement of the plurality of sliding elements with a blade profile of the master key. A key extraction module is configured to retrieve a key blank of an identified key type. A key cutting module is configured to cut the key blank in accordance with a tooth pattern of the master key.

Self service key duplicating machine with automatic key model identification system

Growing community of inventors

Calabasas, CA, United States of America

Daniel Freeman