Oxford Biomedica (uk) Limited

Oxford Biomedica, Inc.

Daniel Farley

Kyriacos Andreou Mitrophanous

Hannah Stewart

Helen Maunder

A cell for producing retroviral vectors comprising nucleic acid sequences encoding: i) gag-pol; ii) env; iii) the RNA genome of the retroviral vector; and iv) optionally rev, or a functional substitute thereof, wherein at least two nucleic acid sequences are located at the same genetic locus; and wherein the at least two nucleic acid sequences are in reverse and/or alternating orientations.

Retroviral vector

The present invention relates to a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell.

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Oxford, United Kingdom

Daniel Farley