The Charles Stark Draper Laboratory, Inc.

Daniel F King

Jonathan Robert Coppeta

David J Carter

William Whitcomb McFarland

Isaac Mayer Ehrenberg

Graham Arrick

Alexander Sawyer

Juliette E Mahaffey

Vishal Tandon

Stephanie Lynne Golmon

Jesse M Carr

Corin Williams

Timothy J Biliouris

A device, system and process involve conducting electroporation of microvesicles or exosomes or other target structures in a microfluidic arrangement at pressures that exceed atmospheric pressure. Single as well as multiple flow configurations can be employed. In some cases, the system and its operation are computer-controlled for partial or complete automation.

Method and device for high field strength electrotransfection of microvescicles and cells

According to various aspects and embodiments, a growth adaptive expandable stent is provided. The expandable stent includes a stent structure having a cylindrical shape that is self-expanding in a radial direction and includes a plurality of cylindrical rings disposed along a longitudinal axis of the stent structure. The stent structure is configured to exert a continuous outward radial force over time when implanted such that a diameter of the stent structure expands from a first value to a second value that is at least about 1.5 times the first value.

Growth adaptive expandable stent

A reservoir provided in a hard-point fixture is pre-loaded with a curable adhesive, where the reservoir is protected from the curing radiation. The fixture is placed on a target surface and the adhesive is extruded from the reservoir into a space between the fixture and the target surface. An irradiating device to cure the adhesive is provided in the fixture and activated to couple the fixture to the surface. Once the curing process is complete, the fixture is released from the placement system leaving the fixture affixed to the target surface.

Hard-point fixture for attaching to a target surface

A hard-point fixture placement system places a fixture that is pre-loaded with a curable adhesive by mechanically extruding the adhesive between the fixture and a target surface to which the fixture is to be attached. The placement system includes an irradiating device to cure the adhesive. The hard-point fixture stores the adhesive in a reservoir that is protected from the curing radiation. Once the curing process is complete, the fixture is released from the placement system leaving the fixture affixed to the target surface.

Hard-point fixture and system for attaching the fixture to a target surface

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Watertown, MA, United States of America

Daniel F King