Baxter International Inc.

Fenwal, Inc.

Baxter Travenol Laboratories, Inc.

Pall Corporation

Baxter Healthcare Inc.

Cerus Corporation

Daniel F Bischof

John R Chapman

Chong-Son Sun

Robert E Herman

Richard C Giesler

Dale R Ellis

Daniel R Lynn

Jean Marie Mathias

Kyungyoon Min

Richard I Brown

Ying-Cheng Lo

William Henry Cork, Iii

Richard L West

Bryan Blickhan

Mark B Jones

Dennis E Van Epps

Robert J Cantu

Richard P Goldhaber

Jeffrey A Martinson

Serge De Gheldere

Veronique Mayaudon

William C Lake

Frederick Aono

Bryan J Blickhan

Yuanpang Samuel Ding

John T Foley

George D Cimino

Jean-Marie Mathias

Jose Castillo Deniega

James Laird

John M Munsch

Ludwig Wolf, Jr

Jean-Claude Bernes

Derek J Hei

William R Bratten

Daniel H Duff

Mahmood Mohiuddin

Peyton S Metzel

Noel Tod Borton

Joseph S Moore

Larry Servi, Jr

Stephanie Haldiman

Mark Alexander Sutter

Matthew E Likens

Gregory Soudant

Lawrence J Servi

George D Dimino

Daniel Baxter SA Lecour

Medical needle assemblies incorporating a needle cover are provided. According to one aspect, the needle cover is integrally formed from a material that: (1) is sufficiently rigid to prevent bending of an underlying cannula, (2) is suitable for allowing a frangible portion thereof to be broken under pre-selected conditions, and/or (3) has a moisture vapor transmission rate sufficient for steam sterilization of a needle tip enclosed by the needle cover. According to another aspect, at least part of a cap portion and a hub portion of the needle cover are translucent. According to yet another aspect, the needle cover is provided with a wing having an enlarged rib suitable for gripping during separation of a cap portion from the remainder of the needle cover.

Phlebotomy needle assembly and frangible cover

Needle covers are provided for medical needle assemblies having a base and a cannula. The needle cover includes hub and cap portions. The hub portion is adapted to be secured to the base. The cap portion is adapted to substantially enclose at least a distal end of the cannula when the hub portion is secured to the base. The cap portion includes at least one generally outwardly extending wing having an outer edge and an enlarged rib extending along only a portion of the outer edge of the wing and only in a direction substantially parallel to a central axis defined by the cap portion. The cap portion is separable from the hub portion upon application of a torsional force, with the rib of the wing being thicker than the portion of the wing radially inward of the outer edge to assist gripping during application of such force.

Methods and apparatus for collecting blood samples in vacuum sample tubes are disclosed. The samples, including the initial blood sample, are substantially free of excess air.

Method and apparatus for blood sampling

Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and methods emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by cellular matter.

Systems and methods for removing viral agents from blood

Systems and methods manually process blood and blood components in sterile, closed environments, which further condition the blood components for subsequent pathogen inactivation processes. The systems and methods mate the manual collection of random donor platelet units with the creation of larger therapeutic doses of platelets targeted to undergo pathogen inactivation prior to long term storage and/or transfusion.

Manual processing systems and methods for providing blood components conditioned for pathogen inactivation

Methods and systems for preparing blood products that are ready for treatment in established pathogen inactivation procedures are disclosed. The methods include providing a source of a blood component and combining the blood component with a synthetic medium in a selected ratio of the blood component to the synthetic media, whereby the resulting blood product is treatment-ready.

Methods and systems for preparing blood products

Blood processing systems and methods establish on line communication between a container and a source of blood containing leukocytes and platelets, such as a human donor. The systems and methods create a centrifugal field between the source of blood and the container that separates from the blood an unfinished suspension of platelets having a first physiologic characteristic different than the desired physiologic characteristic. The systems and methods pump the unfinished platelet suspension outside the centrifugal field through a finishing device. The finishing device changes the first physiologic characteristic to the desired physiological characteristic, thereby creating the finished platelet suspension. The systems and methods convey the finished platelet suspension from the finishing device directly into the container. The systems and methods function without interrupting the on line communication between the container and the source of blood.

Systems and methods for on line finishing of cellular blood products like platelets harvested for therapeutic purposes

Systems and methods treat plasma carrying contaminants and leukocytes that are capable of entraining contaminants. The systems and methods separate leukocytes from the plasma by filtration, thereby removing contaminants entrained within leukocytes. The systems and methods also add to the plasma a photoactive material and emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by leukocytes.

Systems and methods for removing free and entrained contaminants in plasma

Apparatus for withdrawing whole blood from a donor, separating the whole blood to obtain a target cell population and returning a selected one of either the target cell population or at least a portion of the whole blood remainder to the donor or patient. A disposable separation inset for use in association with a rotatable separation device of the apparatus may also be provided. The disposable inset may include a chamber for receiving a cell suspension that includes the target cell, a receptacle for containing particles having a binding site for selectively binding to the target cell and a means for introducing the particles into the chamber.

Apparatus for the separation of biologic components from heterogeneous cell populations

On line blood processing system for obtaining for storage a blood suspension having a reduced residual leukocyte population

Blood separation systems and methods draw whole blood from a blood donor selected from a population of blood donors. The whole blood of the selected blood donor has a known hematocrit value that varies within the population of blood donors according to morphology of the selected blood donor. The systems and methods operate a pump in the inlet line to convey a volume of whole blood from the donor at a commanded flow rate for processing into plasma constituent and concentrated red blood cells. The systems and methods set the commanded flow rate to vary the volume of whole blood conveyed over time as a function of the known hematocrit value of the selected donor. The systems and methods obtain, after processing the whole blood volume, a targeted volume of concentrated red blood cells, which is substantially constant for the population of blood donors despite variances in known hematocrit values among the donors.

Systems and methods which obtain a uniform targeted volume of concentrated red blood cells in diverse donor populations

Apparatus for separating a biological component from a biological fluid are disclosed. The apparatus includes a chamber for receiving a biological fluid including a biological component, and a rotor for creating a centrifugal field within the chamber. A source of particles may be included wherein the particles have a binding site for selectively binding to the biological component. The particles may be aseptically introduced into the chamber. The apparatus may withdraw whole blood from a donor, separate the whole blood to obtain a target cell population and return a selected one of either the target cell population or at least a portion of the whole blood remainder to the donor or patient. A disposable separation inset for use in conjunction with a rotatable separation device such as the apparatus described above may also be provided.

Apparatus for separation of biologic components from heterogeneous cell populations

System and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and methods emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by cellular matter.

A method for purifying conventionally treated blood plasma to remove substantially all residual leukocytes while maintaining useful flow rates for medically useful amounts of plasma utilizes a disposable, heat-sterilizable filter employing one or more depth-type prefilters and at least one intermediate hydrophilic microporous membrane followed by at least one final hydrophilic microporous membrane having a smaller pore size than the intermediate membrane within a common housing. The purified plasma is preferably subjected to chemical treatment to destroy infectious agents such as hepatitis and HIV.

Method for purifying blood plasma and apparatus suitable therefor

Growing community of inventors

McHenry, IL, United States of America

Daniel F Bischof