American Hoechst Corporation

Hoechst Roussel Pharmaceuticals

Daniel Eugene Aultz

Arthur R McFadden

Heteroarylbenzoxepin-acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and processes for their preparation are disclosed. These compounds are useful as antiinflammatory and analgesic agents.

Process for preparing heteroarylbenzoxepin-acetic acids, precursors and

The invention relates to diuretic dihydro-dibenzoxepines-thiepines and -morphanthridones of the formula ##STR1## wherein R is ##STR2## where R.sup.4 is a hydrogen or an alkyl; R.sup.1 is hydrogen or alkyl; R.sup.2 and R.sup.3 are the same or different and are hydrogen, alkyl or R.sup.2 and R.sup.3 are fused to form a pyrrolidino, morpholino, piperidino or azepino ring substituent; Y is hydrogen, halogen and alkoxy, X is ##STR3## where R.sup.4 is as defined above; m is an integer of 0 or 1; and n is an integer of 2 or 3; and the pharmaceutically acceptable acid addition salts thereof.

Dihydro-dibenzoxepines-thiepines and -morphanthridones, compositions and

Oxopyridobenzoxepin acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and processes for their preparation are disclosed. These compounds are useful as antiinflammatory and analgesic agents.

Oxopyridobenzoxepin-acetic acids and derivatives thereof useful as

Oxofuranobenzoxepin-acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and processes for their preparation are disclosed. These compounds are useful as antiinflammatory and analgesic agents.

Oxofuranobenzoxepin-acetic acids, precursors and derivatives thereof

Oxopyrrolobenzoxepin-acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and processes for their preparation are disclosed. These compounds are useful as antiinflammatory and analgesic agents.

Oxopyrrolobenzoxepin-acetic acids, precursors and derivatives thereof

Precursors of heterofuranobenzoxepin acetic acids

Precursors of heterothienobenzoxepin acetic acids

Oxothienobenzoxepin-acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and process for their preparation are disclosed. These compounds are useful as antiinflammatory and analgesic agents.

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Middlesex, NJ, United States of America

Daniel Eugene Aultz