Atreca, Inc.

Kymab Limited

Daniel Eric Emerling

Wayne Volkmuth

Shaun M Lippow

Jeff DeFalco

Sean Matthew Carroll

Tito Serafini

Allan Bradley

Randal Robert Ketchem

Qi Liang

William H Robinson

Yann Chong Tan

Fengling Liu

Vera Huang

Spela Binter

Amy Manning-Bog

Simon James Watson

Alexander Scholz

Nikhil Vad

Katherine L Williams

Norm Greenberg

Jessica Finn

Paul Kellam

Norman Michael Greenberg

Jeff Defalco

The present disclosure provides anti-circumsporozoite (CSP) antibodies, compositions comprising such antibodies. Also disclosed are methods of producing the disclosed antibodies and methods of treating or preventing malaria using the same.

Anti-CSP antibodies

Provided herein are antibodies that bind to tumor tissue through a binding interaction with an extracellular RNA-protein complex. Such antibodies are used in methods of inducing an immune response and methods of inhibiting tumor cell growth. Additionally provided are methods of producing such antibodies.

Antibodies that bind tumor tissue for diagnosis and therapy

Antibodies that bind to the circumsporozoite protein (CSP) of. Use of such antibodies as anti-malarial agents, to confer protection against infection by malarial parasites such asby insect vector transmission. Diagnosis of malaria using anti-CSP antibodies. Methods of determining efficacy of candidate vaccine compositions in development and testing of anti-malarial vaccines.

Anti-malarial antibodies that bind circumsporozoite protein

Disclosed herein are methods and compositions for using nanoexpression to interrogate antigen specificity within antibody repertoires. Also disclosed herein is an antibody display system composition comprising one or more recombinant nucleic acid sequences comprising a first nucleic acid sequence encoding a heavy chain variable region sequence or fragment thereof operatively linked to a first identification region sequence and a second nucleic acid sequence encoding a light chain variable region sequence or fragment thereof operatively linked to a second identification region sequence.

Use of nanoexpression to interrogate antibody repertoires

Growing community of inventors

Redwood City, CA, United States of America

Daniel Eric Emerling