Exosome Diagnostics, Inc.

Daniel Enderle

Johan Karl Olov Skog

Mikkel Noerholm

Johan Skog

Aparna Ramachandran

Tai-Fen Wei

Emily Berghoff

Haoheng Yan

Georg Stoll

Johan Karl Skog

The present disclosure provides compositions, methods and kits for internal controls of microvesicle isolations. The compositions, methods and kits can comprise enveloped viruses, including, but not limited to, inactive mouse hepatitis virus (MHV).

Compositions and methods for internal controls of microvesicle isolations

The invention provides novel methods and kits for isolating nucleic acids from biological samples, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles, and for extracting nucleic acids from the microvesicles and/or from the biological samples.

Methods for isolating microvesicles and extracting nucleic acids from biological samples

The invention provides novel methods and kits for fully automated high-throughput method for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles, novel methods and kits for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles that do not require the use of phenol or chloroform, and for extracting nucleic acids from the extracellular vesicles and/or from the biological samples.

Automated and manual methods for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids

Growing community of inventors

Martinsried, Germany

Daniel Enderle