Bend Research, Inc.

Dow Global Technolgoies LLC

Daniel Elmont Dobry

Dwayne Thomas Friesen

James Mathew Mullin

David Keith Lyon

Douglas Lee Millard

Warren Kenyon Miller

David D Newbold

David Thomas Vodak

Corey Bloom

Roderick Jack Ray

Daniel Tod Smithey

Michael Mark Morgen

Ronald Arthur Beyerinck

John Michael Baumann

Devon Dubose

Rodney James Ketner

Dana Marie Settell

William Brett Caldwell

Devon B DuBose

Kevin Douglas Grove

Douglas L Millard

Heather Lynn Deibele

Kenny Ray Spence

Heather Lynn Melcher Deibele

James Matthew Mullin

Spray drying processes are used to form pharmaceutical compositions comprising a solid amorphous dispersion of a drug and a polymer.

Spray drying processes for forming solid amorphous dispersions of drugs and polymers

Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.

Pharmaceutical compositions of dextran polymer derivatives

A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.

Spray-drying apparatus and methods of using the same

A secondary drying process is disclosed for removing residual solvent from drug-containing particles that have been formed by solvent-based processes, the secondary drying process utilizing a combination of vacuum, agitation, and a stripping gas.

Drying of drug-containing particles

A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A ratio of the length between the first end and second end to a maximum width between opposing internal surfaces of the interior of the drying chamber can be at least 5 to 1.

Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility active agent and such polymers, the polymers provide increased aqueous concentrations and/or improved physical stability of the active agent.

Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution

A secondary drying process is disclosed for removing residual solvent from drug-containing particles that have been formed by solvent-based processes.

Growing community of inventors

Bend, OR, United States of America

Daniel Elmont Dobry