University Of Washington

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Fred Hutchinson Cancer Center

Daniel Ellis

Neil P King

David Baker

William H Sheffler

Jacob Bale

Jorge Fallas

George Ueda

Barney S Graham

Masaru Kanekiyo

Lance Joseph Stewart

Lauren Carter

Brooke Fiala

Jesse Bloom

Allison Greaney

Jing Yang Wang

Tyler Starr

Seyhan Boyoglu-Barnum

Rebecca A Gillespie

Rashmi Ravichandran

Una Nattermann

Nanoparticles and vaccines containing these nanoparticles that elicit an immune response against hemagglutinin (HA) proteins from a broad range of influenza viruses are provided. The nanoparticles are made from self-assembling proteins, at least one of which is joined to an immunogenic portion of an influenza HA protein. This immunogenic portion is displayed on the nanoparticle surface, making the nanoparticles useful for vaccinating subjects against influenza virus.

Nanoparticle-based influenza virus vaccines and uses thereof

Provided herein are compositions and methods comprising mutated coronavirus 'S' spike proteins or receptor binding domains thereof that have an increased expression level, yield and stability compared to its corresponding native or wild-type coronavirus spike protein under the same expression, culture or storage conditions. These mutated spike proteins can be used for generating a protein-based vaccine against one or more coronaviruses.

Stable coronavirus proteins and vaccine compositions thereof

A drinking straw sanitizing appliance includes an exterior housing defining an interior having an adjustable heating element configured to covert a unit of water into steam. The interior is configured to also removable secure drinking straws therein thereby subjecting the same to sanitizing steam when the device is activated. The exterior of the device has a plurality of controls and a lid of the device has a locking mechanism.

Drinking straw sanitizing appliance

Nanostructures and nanostructure-based vaccines that display antigens capable of eliciting immune responses to infectious agents such as bacteria, viruses, and pathogens are provided. Some vaccines are useful for preventing or decreasing the severity of infection with an infectious agent, including, for example and without limitation, lyme disease, pertussis, herpes virus, orthomyxovirus, paramyxovirus, pneumovirus, filovirus, flavivirus, reovirus, retrovirus, meningococcus, or malaria. The antigens may be attached to the core of the nanostructure either non-covalently or covalently, including as a fusion protein or by other means. Multimeric antigens may optionally be displayed along a symmetry axis of the nanostructure. Also provided are proteins and nucleic acid molecules encoding such proteins, vaccine compositions, and methods of administration.

Self-asssembling nanostructure vaccines

Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

Polypeptides for use in self-assembling protein nanostructures

Growing community of inventors

Seattle, WA, United States of America

Daniel Ellis