Astrazeneca Ab

Astra Aktiebolag

Daniel Edvardsson

Anita Lundblad

Ursula Pettersson

Lena Hedstr&ouml;m

Magnus Sj&ouml;gren

Panagiotis Ioannidis

J&ouml;rgen Alvh&auml;ll

Lena Hedstróm

Maria Sz&ouml;nyi

There is provided EtOC&#x2014;CH&#x2014;(R)Cgl-Aze-Pab-OH, or a pharmaceutically-acceptable salt thereof, in a form which is substantially crystalline. It has been found that crystalline forms of EtOC&#x2014;CH&#x2014;(R)Cgl-Aze-Pab-OH have a high chemical and solid state stability when compared to amorphous forms of the compound.

Crystalline forms of EtO2C-Ch2-(R)Cgi-Aze-Pab-OH

Coupling process

There is provided EtO C&mdash;CH &mdash;(R)Cgl&mdash;Aze&mdash;Pab&mdash;OH, or a pharmaceutically-acceptable salt thereof, in a form which is substantially crystalline. It has been found that crystalline forms of EtO C&mdash;CH &mdash;(R)Cgl&mdash;Aze&mdash;Pab&mdash;OH have a high chemical and solid state stability when compared to amorphous forms of the compound.

Crystalline forms

There is provided EtO,C&mdash;CH,&mdash;(R)Cgl&mdash;Aze&mdash;Pab&mdash;OH, or a pharmaceutically-acceptable salt thereof, in a form which is substantially crystalline. It has been found that crystalline forms of EtO,C&mdash;CH,&mdash;(R)Cgl&mdash;Aze&mdash;Pab&mdash;OH have a high chemical and solid state stability when compared to amorphous forms of the compound.

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Södertälje, Sweden

Daniel Edvardsson