General Electric Company

Amgen Inc.

Ge Medical Systems Global Technology Company, LLC

Stryker European Holdings I LLC

Daniel Eduardo Groszmann

Scott Robert Gibson

Mehran Mojarrad

Sudeshna Dutta Ray

Yves Lucien Trousset

Lawrence Scott Ring

Michel Francois Grimaud

Laurent Jacques Node-Langlois

William Hullinger Huber

Vernon Jensen

Paul D Faucher

Ella Zaslavsky

Jonathan David Schiff

Tina Kapur

Alan D Payne

Mikhail Tikh

Robert Allen Dees

Taylor Braun-Jones

Nathan Thomas Balcom

Alejandro Campillo-Agusti

Sheldon B Moberg

Kaustubh Ravindra Nagarkar

Peter Traneus Anderson

Christopher Allen Nafis

Dun Alex Li

Wael Mismar

Jon Thomas Lea

Vianney Pierre Battle

Hubert Anthony Zettel

Jimmie L Ward

Jeremie Pescatore

Matthew Wayne Janke

Joshua Tamsky

Gerald Lee Beauregard

Samin Akbari

Tohid Pirbodaghi

Joel Zuhars

Jonathan Dean Johnson

Antonio S Murcia

Jeff Lind

Andrew James Carlson

Lee Gordon Macklem

Ron Andrew Von Jako

Mark Gordon

Joel F Zuhars

Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.

Modular fluid path assemblies for drug delivery devices

Fluid path assemblies for drug delivery devices and methods of establishing a fluid flow path for drug delivery devices are described that include a needle shield valve member that couples to a reservoir having a needle mounted thereto. The needle shield valve member includes an internal barrier that protects the needle and/or contains a drug within the reservoir until activation of the drug delivery device. Upon activation, there is relative movement between the reservoir and needle shield valve member until the needle pierces the barrier to establish a fluid flow path from the reservoir through the needle shield valve member.

Fluid path assembly for a drug delivery device

Drug delivery devices are described that include an escapement activation assembly. The escapement activation assembly includes a slide having a plurality of pallet engagement portions and a switch engagement portion and a pallet having a plurality of slide engagement portions. A drive is coupled to the pallet to cause the pallet to move relative to the slide to move the plurality of slide engagement portions into and out of engagement with the plurality of pallet engagement portions to allow the slide to move along a path within the drug delivery device. Movement of the slide can cause the switch engagement portion to move out of engagement with an activation trigger of a mechanism of the drug delivery device.

Muscle wire escapement activation assembly for a drug delivery device

A drug delivery device includes a housing defining a shell and an inner volume, a container, a drive mechanism, a needle assembly, a fluid flow connection, and a backflow prevention mechanism. The container has an inner volume to contain a medicament to be administered to a user. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the medicament out the container. The fluid flow connection is coupled to the container and the needle assembly and allows the medicament to flow from the container to the needle assembly to be administered. The backflow prevention mechanism is associated with at least one of the container, the fluid flow connection, or the needle assembly and includes at least one flow restrictor to restrict a fluid from flowing from the needle assembly to the container.

Backflow prevention mechanism for drug delivery device

A flexible plunger rod, drug delivery mechanism, drug delivery device, and methods are described that utilize the flexible plunger rod perform drug delivery operations. In embodiments, the flexible plunger rod can be stored in a curved configuration to thereby reduce a footprint of the drug delivery mechanism and device.

Drug delivery mechanism

Systems and methods for injecting a drug and detecting tissue induced back pressure are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, an administration member connected or connectable in fluid communication with the reservoir, a drive assembly, and a pressure sensor. The administration member may be configured for insertion into and subsequently retraction from a patient. The drive assembly may be configured to urge the drug from the reservoir to deliver a dose of the drug to the patient via the administration member. The pressure sensor may be configured to detect tissue back pressure during use of the drug delivery system, including after dose completion and prior to retraction of the administration member. The drug delivery system may be controlled in a manner that accounts for the tissue back pressure measurement.

Drug delivery systems and methods with back pressure sensing

Systems and methods for drug delivery with pressure sensitive control are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, a drug delivery device coupled to the reservoir to deliver the drug from the reservoir to a patient, a pressure sensor, an output device, and a controller. The controller may be configured to determine if the drug delivery device has completed delivering a dose of the drug to the patient, and if delivery of the dose of the drug is complete, to measure tissue back pressure using the pressure sensor. Subsequently, the controller may be configured to determine if the tissue back pressure is below a first predetermined value, and if so, control the output device at least once and/or control a mechanism to retract an administration member from the patient.

Drug delivery systems and methods with pressure sensitive control

An interventional device configured for placement in or near an internal organ or tissue is provided. The interventional device includes a reference portion having three or more sensor elements. In one implementation, the interventional device and associated sensor elements provide dynamic referencing of the internal organ, tissue or associated vasculature after registration of the sensor data with images and/or volumetric representations of the internal organ or tissue.

Dynamic reference method and system for interventional procedures

Display screen portion with animated graphical user interface of C-arm machine

Display screen portion with graphical user interface of C-arm machine

A hybrid tracking system utilizing at least one combined light emitting diode (LED) and magnetoresistance sensor. The hybrid tracking system includes optical tracking technology and electromagnetic (EM) tracking technology with at least one combined LED and magnetoresistance reference sensor attached to a fixed object, at least one combined LED and magnetoresistance sensor attached to an object being tracked, and a processor coupled to the at least one combined LED and magnetoresistance reference sensor and the at least one combined LED and magnetoresistance sensor for processing signals from the at least one combined LED and magnetoresistance reference sensor and the at least one combined LED and magnetoresistance sensor. The combined LED and magnetoresistance sensor includes at least one magnetoresistance sensor and at least one LED that are integrated into a single package.

Hybrid tracking system utilizing combined LED and magnetoresistance sensors

A substrate configured for placement on an internal organ or internal tissue is provided. In certain embodiments, the substrate conforms to and moves with the internal organ or internal tissue. Three or more sensor elements are integrated on the substrate. In one implementation, the substrate and associated sensor elements provide dynamic referencing of the internal organ or internal tissue after registration of the sensor data with images and/or volumetric representations of the internal organ or internal tissue.

Dynamic reference method and system for use with surgical procedures

A navigation system for use during a surgical procedure is provided. The navigation system is configured to use electromagnetic tracking data produced by electromagnetic tracking devices and 2D image data produced by a fluoroscope to intra-operatively register 2D images of a patient to a pre-operative 3D image of the patient. In some implementations, a surgeon may be able to perform an interventional or surgical procedure guided by the navigation system.

Intra-operative registration for navigated surgical procedures

A sensor assembly is provided for use in tracking a medical device. The sensor assembly comprises a magnetoresistance sensor capable of providing position and orientation information. In certain implementations, the magnetoresistance position and orientation sensor is originally configured for connection to a substrate using one type of interconnect approach but is modified to be connected using a different interconnect approach.

Sensor assembly for use in medical position and orientation tracking

Growing community of inventors

Cambridge, MA, United States of America

Daniel Eduardo Groszmann