University of Pittsburgh

University of Medicine and Dentistry of New Jersey

Daniel E Kadouri

Robert Michael Queen Shanks

Robert M Q Shanks

Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolatedcolicin A polypeptide, wherein the polypeptide has an antibacterial activity against the planktonic bacteria or the biofilm. Methods are also provided herein for treating a subject that has a bacterial infection, for example caused by a biofilm. The methods can be used to treat a biofilm on a living or non-living surface. Also provided herein arecolicin A polypeptides that have an antibacterial activity against planktonic bacteria or surface attached bacteria, and nucleic acid sequences encoding the polypeptides. Medical devices comprising a surface having an antimicrobial effective amount of acolicin A polypeptide, or a nucleic acid molecule encoding the polypeptide, are also disclosed.

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Livingston, NJ, United States of America

Daniel E Kadouri