Battelle Memorial Institute

Battelle Pulmonary Therapeutics, Inc.

Daniel Duane Meek

Gregory A Trees

William Godwin Atterbury

Chad Edward Bouton

James E Dvorsky

David Arthur Holley

Anthony Rocco Imondi

Peter Andrew Gaydos

David R Busick

Kevin Sanford Blythe

Andrew O Ross

An improved Electrohydrodynamic (EHD) nozzle particularly suitable for a handheld pulmonary aerosol inhaler increases the consistent and efficient dispensing of therapeutic liquids by reducing or eliminating wetting through shielding of discharge electrodes. Some versions further eliminate wetting while enhances neutralization of the aerosol through presentation of a corona wind of ions annularly surround the aerosol. Incorporation of improved liquid distribution with consistent pressure drops to each EHD nozzle tip allows horizontal dispensing, and by using dielectric nozzle tips with low surface energy to thereby avoid wicking between dispenses and to advantageously reduce achievable particle size when dispensing. Some versions feature enhanced snap-fit assembly and other manufacturability advantages. One of the unique features of the EHD nozzles is achieved high dose rate (microliters/minute) with low wetting and small particle size (1.0-5 microns), although these properties tend to be mutually exclusive. Furthermore, these attributes are incorporated into a conveniently small, handheld device.

Nozzle for handheld pulmonary aerosol delivery device

A pulmonary dosing system and method for supplying to a patient a predetermined amount of respirable therapeutically active material is disclosed. The system comprises a patient interface to introduce the material into the patient's lungs and an apparatus for providing pulsed amounts of the material to a plenum chamber. The plenum chamber has a diffuser baffle which increases the efficiency of the dosing system by preventing axial flow of the active material thereby utilizing the available volume of the chamber for holding the aerosolized drug prior to inhalation.

Pulmonary dosing system and method

Growing community of inventors

Canal Winchester, OH, United States of America

Daniel Duane Meek