Sanofi

Sanofi-a Ventis Deutschland Gmbh

Hoffmann-la Roche Inc.

Unilever IP Holdings B.v.

Unilever Global IP Limited

Daniel David Higgins

Matthew Meredith Jones

Mark Digby Teucher

Stefan Blancke

Stephen Francis Gilmore

James Anthony West

James Robert Coop

Ralph Donald Quentin Collings

Michael Jugl

David Aubrey Plumptre

Robert F Veasey

Simon Lewis Bilton

Joseph Butler

Anthony Paul Morris

Axel Teucher

William Marsh

Michael Cameron Bainton

William Geoffrey Arthur Marsh

Sophie Louise Sladen

Malcolm Stanley Boyd

Paul Richard Draper

Samuel Steel

Daniel Thomas De Sausmarez Lintell

Naceur Rekaya

David Martin Leak

Maxime Gaillot

Roberta Leah

Declan Reilly

Benjamin George Oglesby

Jack Carroll

Denny Lustosa Horn

Andrea Ceccaroni

Oliver Needham

David Aubrey Plumtre

Timothy Robin Quigg

Laura Stein

Adil Faysal Kadar

Timothy Huw Gray

Simon Paul Gregory

Colin Marc Webb

A drive train for a wind-up injection device, comprises a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle coupled with a button, a rotationally drivable expelling mechanism, and a clutch element coupled with the torsional energy storage via the rotatable element and comprising a ratchet for maintaining the rotatable element at one of a number of discrete angular positions, wherein via the rotatable element, the clutch element is adapted to transmit a torque from the user handle to the torsional energy storage or from the torsional energy storage to the expelling mechanism, and wherein the ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage, and wherein the drive train is adapted to dampen torque peaks by a flexible impact portion in the area of the clutch element.

Drive train for dial of a torsion-spring assisted wind-up injection device

A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Button and button assembly for a drug delivery device

A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

A drive mechanism for a drug delivery device with a reduced operating loudness includes a dose selector, a housing, and a ratchet with a gear element comprising a plurality of gear teeth connected with the dose selector and a pawl element rotationally constrained to the housing comprising at least one pawl tooth. The at least one pawl tooth engages with the gear teeth and is located opposite to the gear teeth. One of the gear element and the pawl element moves forth and back relative to the other element of the gear and pawl elements along a first direction for de-engagement and re-engagement of the opposite gear teeth and at least one pawl tooth when the gear element rotates relative to the housing during dose setting using the dose selector. The pawl element and/or gear element comprises a noise reduction characteristic at a surface which dampens the noise produced.

Drive mechanism with noise reduction

A system comprises a first member, a second member, and a third member, wherein the first and second members are rotatable relative to the third member, wherein the first and second members are coupled to one another by a dead-angle follower coupling, wherein the dead-angle follower coupling is configured such that the first and second members are rotatable relative to one another, wherein the second and third members are rotationally coupled to one another by a switchable coupling mechanism, wherein the switchable coupling mechanism is switchable between two different states, a locked state and a non-locked state, wherein the maximum torque transferable between the second and third members via the switchable coupling mechanism in the locked state is greater than in the non-locked state, wherein the switchable coupling mechanism is in the locked state when the first member is in a locking position relative to the second member.

Ratchet systems for drug delivery devices

A drive mechanism () for use in a drug delivery device () is provided. The drive mechanism () comprises a housing () with a proximal and a distal end and a piston rod () which is rotatable with respect to the housing (). The drive mechanism () further comprises a nut member () which is selectively rotationally lockable with respect to the housing (), wherein the drive mechanism () is switchable between a setting mode of operation and a dispensing mode of operation. The drive mechanism () is configured such that in the setting mode of operation, the nut member () and the piston rod () are rotatable with respect to the housing (), and in the dispensing mode of operation, the piston rod () is rotatable with respect to the housing () and the nut member () is rotationally locked with respect to the housing (), wherein, when the piston rod () rotates, the piston rod () moves distally with respect to the nut member ().

Drive mechanism for a drug delivery device

An adapter includes a body piece with an open container end side and a dispenser end side opposite to the container end side, and a collar piece arranged around the body piece. The dispenser end side of the body piece has an orifice. The body piece has a longitudinal axis, a cylindrical outer surface, and a cylindrical inner surface with a container thread oriented towards the container end side. The cylindrical outer surface of the body piece is equipped with a cap thread oriented towards the dispenser end side. The cap thread is arranged to interact with an inner thread of the cap for providing a child resistant closure. A collar piece is connected to the body piece that is freely rotatable relative to the body piece around the longitudinal axis of the body piece. The adapter can be used for efficiently and safely connecting a dispenser to container.

Adapter for connecting a dispenser to a container

The invention refers to an injection device comprising a housing (), containing a cartridge () with an amount of liquid to be dispensed, a drive sleeve (), which is rotationally constrained to the housing () during dose setting and spring driven rotatable relative to the housing () during dose dispensing, a dose dial member () for setting a dose to be dispensed, which is rotatable relative to the housing () during dose setting and during dose dispensing, and which is rotationally coupled to the drive sleeve () during dose dispensing. The device further comprises a last dose protection mechanism () for preventing the setting of a dose, which exceeds the amount of liquid left in the cartridge (), with a limiter (), which is interposed between the drive sleeve () and the dose dial member (). Further, the device comprises two different display members (), each indicating the set dose.

Injection device

The present disclosure concerns an attachment for an operable drug delivery device, comprising a gripping sleeve member that is configured to receive a first member of the operable drug delivery device, wherein the gripping sleeve member comprises a first gripping sleeve member part comprising a first engagement feature at its inner surface that is configured to engage the first gripping sleeve member part in a torque-proof manner with the first member of the operable drug delivery device. Further, the present invention concerns a use of the attachment or a system of attachments for operating the operable drug delivery device.

Add-on grip and actuation-sleeve for a pen-type drug injection device

The present invention relates to a dispensing speed control mechanism for use in an injection device. The injection device may have a housing ('&#x2033;) and a drive member (), which is driven by a power reservoir (&#x2032;) and axially movable between a dose setting position, in which the drive member () is rotationally constrained to the housing (&#x2032;&#x2033;), and a dose dispensing position, in which the drive member () is rotationally de-coupled from the housing (&#x2032;&#x2033;). The speed control mechanism comprises friction means () for retarding the drive member () during dose dispensing depending on the axial position of the drive member (). Further, the invention relates to an injection device with such a dispensing speed control mechanism.

Dispensing speed control mechanism and injection device

A drug delivery device having a spring element that provides dispense assistance. The drug delivery device includes a variable dose setting mechanism, a fixed dose setting mechanism, and a mechanical coupling having a spring element. The variable dose setting mechanism is operably coupled to a first reservoir holding a first medicament, and the variable dose setting mechanism comprises a dose setter. The fixed dose setting mechanism is operably coupled to a second reservoir holding a second medicament. The mechanical coupling operably couples the variable dose setting mechanism and the fixed dose setting mechanism. Further, the variable dose setting mechanism is configured to set a variable dose of the first medicament upon activation of the dose setter, and the fixed dose setting mechanism is configured to set a fixed dose of the second medicament during variable dose setting. Still further, the spring element is configured to store energy during dose setting and to transfer stored energy to the fixed dose setting mechanism to assist with dispense of the fixed dose.

Drug delivery device having a spring element

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Bristol, United Kingdom

Daniel David Higgins