Caris Mpi, Inc.

The Translational Genomics Research Institute

The University of Arizona

Daniel D Von Hoff

Robert J Penny

Matthew J McGinniss

Alan Wright

Ryan P Bender

Traci Pawlowski

Arlet Alarcon

David M Loesch

Haiyong Han

Hongwei Yin

Caroline Huynh Diep

Gary A Flynn

Hong Wang

Christine Kuslich

Matthew J Mcginnis

Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.

Molecular profiling of tumors

Methods of tests that assess the expression of DPC4 (SMAD4) to identify subjects with pancreatic cancer that are likely or unlikely to respond to treatment with BTK inhibitors; methods of treating subjects based on identification of the subjects as likely to respond to treatment with BTK inhibitors; therapeutic targets for cancers, particularly cancers with inactivated DPC4 gene or protein; methods of screening of new therapeutic agents using the target; pharmaceutical composition comprising BTK inhibitors, such as PCI-32765 or derivatives thereof, for cancer treatment; and kits that facilitate the performance of the methods are disclosed.

Methods and kits to predict therapeutic outcome of BTK inhibitors

A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.

System and method for determining individualized medical intervention for a disease state

Growing community of inventors

Phoenix, AZ, United States of America

Daniel D Von Hoff