Kinex Pharmaceuticals, LLC

Hypnion, Inc.

Colucid Pharmaceuticals, Inc.

Athenex, Inc.

Daniel Coughlin

James F White

Kazumi Shiosaki

David G Hangauer, Jr

David G Hangauer

Michael E Solomon

Dale M Edgar

Jonathan B Gale

Jeremy A Cody

Debasis Patra

Grant Jackson Palmer

Paul Kenneth Isbester

Jonathon Salsbury

J David Leander

Nadia M J Rupniak

Shoucheng Du

Jonathan Gale

Michael Solomon

The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy) phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.

Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof

The invention includes benzisoxazole piperidine compositions and methods of using them for modulating sleep.

Benzisoxazole piperidine compounds and methods of use thereof

Compounds that inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. The compounds of the invention are employed in methods to treat an individual. The pharmacologically active agent obtained by hydrolysis of the compound can treat, for example, a nervous system condition, a cholinergic deficiency and conditions or diseases associated with a deficiency in a pharmacologically active agent, such as acetylcholine.

Compounds that inhibit cholinesterase

The invention includes benzisoxazole piperazine compositions and methods of using them for modulating sleep.

Benzisoxazole piperazine compounds and methods of use thereof

The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.

The invention relates to compounds and methods for modulating one or more components of a kinase cascade.

Composition and methods for modulating a kinase cascade

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Hackettstown, NJ, United States of America

Daniel Coughlin