Hemotec, Inc.

Hierath & Andrews Corp.

Daniel Cooper

Jacqueline J Jackson

James S Andrews

Robert F Baugh

Walter Jacob Braun

Anatoly Dvornichenko

A method and apparatus for rapidly and accurately dispensing measured amounts of powdered material from a vibratory feeder with a shaker rod extending through an orifice at the discharge end of the feeder and which rod undergoes reciprocal movement in response to vibration of the feeder to regulate the advancement of the powdered material. Alternate forms of control algorithms are employed in association with a computer to determine the optimum rate of feed and drive level for a given powder and feeder arrangement to result in a specific final weight within an acceptable tolerance for each fill cycle.

Weighing and filling method and apparatus

Coagulation is detected in a fluid sample such as blood which has been inserted into a cartridge and operated on by an actuator mechanism. The cartridge may be of either of two types: a plunger sensor cartridge wherein a plunger assembly is reciprocated in a predetermined manner within the fluid sample and the descent of the plunger assembly is sensed to determine coagulation conditions, and a gas flow cartridge wherein gas is passed through the fluid sample to transmit liquid in bubbles and the accumulation of the coagulating liquid from the bubbles is sensed to detect coagulation. An actuator mechanism operates with either one or both types of cartridges to create the conditions under which coagulation can be detected and to sense the coagulation detection conditions. The actuator mechanism reciprocates the plunger assembly and forces gas through the liquid sample to create the bubbles.

Apparatus for coagulation detection by gas flow or plunger sensing

A gas flow cartridge in which to conduct analytical coagulation tests on a sample of fluid such as blood includes a tube-like member and a resilient flexible membrane having a slit formed therethrough to divide the tube-like member into an upper reaction chamber in which the test takes place and into a lower reagent chamber which initially contains reagent to be mixed with the sample of liquid upon which the test is to be conducted. The contents of the reagent chamber are forced through the slit in the resilient flexible membrane due to the flexing of the membrane around the slit when pressure is applied. Once the reagent is in the reaction chamber with the sample of fluid, a flow of gas is forced upward through the slit in the membrane during the analytical test.

Gas flow cartridge having resilient flexible membrane with slit

Coagulation is detected in a fluid sample contained in either a gas flow cartridge or a plunger sensor cartridge, either one of which may be inserted in an actuator mechanism which has the capability of acting on either type of cartridge. Coagulation is detected in the gas flow cartridge by optically sensing the accumulation of coagulating liquid in a foam member at the top of the reaction chamber. In the plunger sensor cartridge, a plunger assembly is raised and released to descend through the sample of liquid in the bottom of the reaction chamber. The plunger assembly descends more slowly upon an increase in the viscosity of the fluid sample due to coagulation. Both cartridges include a lower reagent chamber, an upper reaction chamber, and means initially sealing and thereafter communicating the contents from the reagent chamber to the reaction chamber. The actuator mechanism includes means for delivering the flow of gas to the gas flow cartridge and means for reciprocating the plunger assembly in the plunger sensor cartridge.

Coagulation detection by plunger sensing technique

A gas flow cartridge in which to conduct a coagulation-related test uses an elongated pin member movably positioned within a communication opening which separates a reagent chamber from a reaction chamber. A first portion of the pin member has an operative configuration for sealing the communication opening when the first portion is positioned in the communication opening. A second longitudinally displaced portion of the pin member opens the communication opening to further communication therethrough upon longitudinal movement of the pin member. At the commencement of an analytical test, a plug member is moved upwardly to contact the pin member and move the first portion out of the communication opening and the second portion into the communication opening. The upward movement of the lower plug member forces the contents of the reagent chamber through the opened communication opening and into the reaction chamber. A pointed needle-like member pierces a membrane of the lower plug member and injects gas into the cartridge. The gas also flows through the opened communication opening.

Growing community of inventors

Parker, CO, United States of America

Daniel Cooper