Keio University

National Institute of Advanced Industrial Science and Technology

The University of Tokyo

Techno Medica Co., Ltd.

Daniel Citterio

Koji Suzuki

Atsushi Ikeda

Moritoshi Sato

Takahiro Nakajima

Hiroshi Makino

Tomohiro Yamamoto

Sung-Bae Kim

Kenichi Maruyama

Hiroki Yamazaki

Ryo Nishihara

Keitaro Umezawa

Saeko Ishihara

Yoshio Araki

Masafumi Hagiwara

Kazushi Misawa

[Problem to be solved by the invention] The purpose of the present invention is to provide a competitive immunochromatographic analysis method and immunochromatographic sensor using said analysis method capable of intuitively displaying a molecular concentration of a substance to be measured and facilitating visual judgement of the molecular concentration. [Problem to be solved by the invention] Competitive immunochromatographic analysis method according to the present invention is characterized in that the method comprises

Competitive immunochromatographic analysis method and immunochromatographic sensor

There is provided a series of coelenterazine (CTZ) derivatives as a substrate with high luminescence intensity, which is optimal for maximum luminescence wavelengths at both 400 nm (blue-shifted RLuc luminescence system) and 500 nm (ALuc luminescence system) for bioassays which is more sensitive than known techniques. The novel CTZ derivatives are compounds in which a specific position(s) of the CTZ is/are substituted with a specific substituent(s) as shown, for example, by the Formula [I], and has a higher luminescence intensity than known CTZ derivatives in blue-shifted RLuc luminescence system or ALuc luminescence system.

Coelenterazine compounds and uses thereof

A novel fluorescent compound having a high light fastness, high fluorescence quantum yield and sharp absorption spectrum, which emits fluorescence having a wavelength in long wavelength region, as well as its use as a labeling agent, is disclosed. In Formula [I] below, by forming a specific hetero ring(s) with Rand R, and/or Rand R, shift of the wavelength of the fluorescence to longer wavelength and increase in molar extinction coefficient are attained maintaining the high light fastness, high fluorescence quantum yield and sharp absorption spectrum which the fluorescent dyes having the boron dipyrromethene skeleton have. 

Fluorescent compound and labeling agent comprising the same

A method for measuring tastes, which can better simulate the human gustation than known methods, as well as a taste sensor, computer program and an apparatus for measuring tastes, is disclosed. In this method, data processing is carried out by a two-phase radial basis function neural network. That is, by sensors, each of which sensors can quantify at least one component representing, individually or cooperatively, the taste of saltiness, sourness, sweetness, umami or bitterness, to obtain a response value from each sensor, and each of the obtained response values is input to a first phase radial basis function neural network to calculate the concentration of each component from each response value. Then, the concentration of each component is fed into a second phase radial basis function neural network, which correlates the concentration of each component with the intensities of saltiness, sourness, sweetness, umami and bitterness sensed by humans, to calculate the intensities of saltiness, sourness, sweetness, umami and bitterness sensed by humans.

Method of measuring taste using two phase radial basis function neural networks, a taste sensor, and a taste measuring apparatus

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Yokohama, Japan

Daniel Citterio