Clemson University

Daniel C Whitehead

James C Morris

Chandima J Narangoda

Frank Alexis

A drug product and method for treating a parasitic disease in a host is described. The drug product comprises: a carrier matrix; and a drug substance having the formula:  wherein: Ris selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons; each Ris independently selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons; Y represents those elements necessary to form a 5 or 6 membered ring; X is selected from the group consisting of B, O, N, S, Se and P; and n is 1-4 as necessary to complete the valence of X.

Diazacyclobutene derivatives as anti-parasitic drug substances

Provided is a compound having the formula: wherein:Ris selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons;Ris selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons;each Ris independently selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons;X is selected from the group consisting of B, O, N, S, Se and P; andn is 1-4 as necessary to complete the valence of X formed by the reaction of a compound of Formula III: and a compound of Formula IV: 

Diazacyclobutene derivatives and methods of synthesis thereof

Contaminant treatment methods and systems are described. Methods utilize biodegradable, non-toxic materials that can carry one or more functionalities useful for the remediation of fluids such as liquid or gaseous waste streams, chemical spills, etc. The carrier materials carry one or more functional groups that can target particular contaminants of a fluid for removal and/or modification to a more benign form. Targeted contaminants can include components of gaseous and/or liquids such as, and without limitation, gaseous discharges including VOCs and potentially hazardous contaminants such as organophosphorous compounds.

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Clemson, SC, United States of America

Daniel C Whitehead