Chiron Corporation

USA As Represented by Secretary of the Navy

Daniel C St Louis

Douglas J Jolly

Harry E Gruber

Jack R Barber

James G Respess

Paul K Laikind

Sunil D Chada

John F Warner

Carl H June

Bruce L Levine

James L Riley

Stephen M W Chang

Richard G Carroll

Stephen M Chang

Methods for modulating HIV-1 fusion cofactor expression by manipulating an accessory molecule on the surface of T cells, such as CD28, are described. The invention encompasses methods for modulating HIV-1 fusion cofactor expression by stimulating or inhibiting one or more intracellular signals which result from ligation of a surface receptor on a T cell which binds a costimulatory molecule. In one embodiment, expression of an HIV-1 fusion cofactor, such as CCR5, is downregulated by stimulating a CD28-associated signal in the T cell.

Methods for downregulating CCR5 in T cells with anti-CD3 antibodies and anti-CD28 antibodies

Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.

Method for inhibiting human tumor cells

Method for making reflection defective retroviral vectors for infecting

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Rockville, MD, United States of America

Daniel C St Louis