Henry Ford Health System

Daniel C Morris

Michael Chopp

Zhenggang Zhang

Lei Wang

Without limitation, some embodiments comprise a method of treatment for promoting recovery of peripheral neuropathy in a subject, including administering to a subject in need of such treatment a therapeutically effective amount of a composition comprised of thymosin beta 4, amino acid sequences LKKTET or LKKTNT, and/or any conservative variants thereof, or an agent that stimulates production of any of those materials, or a conservative variant thereof.

Methods, systems, and compositions for promoting recovery of peripheral neuropathy

Thymosin &#x3b2;4 can be used to treat neuronal and brain injuries that are accompanied by neuronal cell death or injury, including injuries caused by stroke or trauma and injuries caused by neurological and neurodegenerative disease. In particular, stroke and multiple sclerosis are examples of conditions which may be ameliorated by treatment with thymosin &#x3b2;4. Thymosin &#x3b2;4 has been found to restore neurological tissue through several effects on several neurological parameters which are improved by administration of thymosin &#x3b2;4 to a subject in need of neurological tissue restoration. For example, thymosin &#x3b2;4 improves axonal myelination, migration of neural progenitor cells, neural progenitor cell proliferation, differentiation of neural progenitor cells into mature neurons, differentiation of neural progenitor cells into mature glia, nerve regeneration, and brain remodeling at locations of brain injury.

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Grosse Point Park, MI, United States of America

Daniel C Morris