Amgen Inc.

Teijin Pharma Limited

Daniel C H Lin

Julio Cesar Medina

Jonathan B Houze

Liusheng Zhu

Jian Luo

Zhihua Ma

Rajiv Sharma

Jiwen Liu

Yingcai Wang

Jian Zhang

Michael J Schmitt

Jinqian Liu

Stephen J Shuttleworth

Jeffrey D Reagan

Michelle Akerman

Wei Qiu

Ying Sun

Yang Li

Matthew M Weiss

Ryan D White

Angel Guzman-Perez

Laurie B Schenkel

Michael D Bartberger

Daniel B Horne

Zihao Hua

Nagasree Chakka

John Stellwagen

Benjamin Charles Milgram

Jane Panteleev

Jinghong Wang

Hua Gao

Madeleine Kieffer

Wei Zhao

Angel Guzman-perez

Jinqain Liu

The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof. 

Benzimidazole derivatives and their uses

Methods of treating or ameliorating metabolic diseases using a PLA2G12A polypeptide or PLA2G12A mutant polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes mellitus, obesity, dyslipidemia elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ-L-P-L-M-X-L-Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ&#x2014;L&#x2014;P&#x2014;L&#x2014;M&#x2014;X&#x2014;L&#x2014;Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

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Redwood City, CA, United States of America

Daniel C H Lin