University of Colorado

Other

Daniel C F Chan

John M Stewart

Lajos Gera

Paul A Bunn, Jr

Paul Bunn

Eunice York

The invention provides bradykinin antagonists and pharmaceutically acceptable salts thereof having anti-cancer activity. These anti-cancer compounds are particularly useful for inhibiting the growth of lung and prostate cancers.

Anti-cancer compounds

The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula:[ACA]-X[Formula I]wherein X is a linker group having 2&#x2013;5 functional groups or is absent, n=1, and ACA is selected from the group consisting of Formula II, Formula III, Formula IV, Formula V, and Formula VI, as described herein. Other compounds described herein are defined by the Formula VII, as described herein.

Anti-cancer compounds and methods related thereto

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Denver, CO, United States of America

Daniel C F Chan