Abbott Laboratories Corporation

Abbvie Inc.

Ecole Polytechnique Federale De Lausanne

Daniel C Bertrand

Murali Gopalakrishnan

Eugene Stanley Maslana

Peter M Bojan

Jeffrey Y Pan

Earl J Gubbins

Clark A Briggs

John Malysz

Jinhe Li

David J Anderson

Jonathan D Trumbull

David G McKenna

Matteo Leonardi

Stefan Metz

Peter Leuenberger

David P Blanchard

Steven C Cassar

Thomas A Nemcek

The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of &#x3b1;7 nicotinic acetylcholine receptors.

Cholinergic/serotoninergic receptor and uses thereof

A new noninvasive approach for intraocular pressure (IOP) measurement allowing continuous monitoring over prolonged periods, regardless of patient's position and activities. The key element of this measurement method is a soft contact lens () including at least one strain gage () longitudinally arranged around the center of the contact lens and capable of measuring precisely spherical deformations of the eyeball induced by the changes in IOP. This information is transmitted with wires or (preferably) wirelessly in real time to an external recording system (). The system is placed in the same way as a normal corrective contact lens, no anesthesia is required and patient vision remains almost completely unimpaired.

Intraocular pressure recording system

A method and apparatus for running a plurality of tests concurrently to obtain data relating to the electrophysiological properties of receptors and channels in biological membranes of test subjects, such as, for example,oocytes. The invention further provides software for controlling, acquiring, and recording data relating to electrophysiological properties of receptors and channels in biological membranes of test subjects, such as, for example, oocytes. This invention increases the throughput rate for experiments and assays employing receptors and ion channels expressed in biological membranes of test subjects, such as, for example, oocytes. In the case of an oocyte, these receptors and channels may be natively expressed (endogenous), may be placed into the oocyte (exogenous), or may be expressed from other RNA or DNA previously placed into the oocyte (exogenous). The invention provides a means for a sole researcher to operate a plurality of electrophysiological test stations in the time and space conventionally required by a single electrophysiological test station. The invention automates these stations and provides a means for a sole individual to perform large sets of experiments that would be physically and mentally exhausting in the absence of this invention. In addition, this invention provides efficient database and data analysis software integrated with the data acquisition software, thereby increasing the user's data-handling productivity to keep pace with the augmented data generation capacity.

Apparatus and method for electrophysiological testing

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Geneva, Switzerland

Daniel C Bertrand