Egis Gyogyszergyar

Egyt Gyogyszervegyeszeti Gyar

Egis Gyogyszergyar Rt.

Patentbureau Danubia

Egis Gyoyszergyar Rt

Daniel Bozsing

Pal Benko

Karoly Magyar

Peter Tompe

Gyula Simig

Gabor Blasko

Kalman Nagy

Janos Gundel

Attila Mandi

Gabor Gigler

Istvan Gyertyan

Istvan Gacsalyi

Frigyes Gorgenyi

Andras Egyed

Ivan Beck

Istvan Simonyi

Laszlo Levai

Eva Furdyga

Janos Imre

Eva J Tajthy Nee Juhasz

Gyorgyi Zalavari Nee Dosa

Erzsebet Kiss Nee Bertok

Ilona Dinnyes Nee Nagy

Eva Poczik

Gyorgy Mikite

Gyorgyi Kovanyi Nee Lax

Csaba Szantay

Lujza E Petocz

Gabor Kovacs

Gabor Nemeth

Katalin Szemeredi

Eva Schmidt

Lajos Novak

Maria Szecsey Nee Hegedus

Gyorgy Krasznai

Margit Csorgo

Karoly Tihanyi

Andras Bilkei-Gorzo

Sandor Drabant

Peter Kovacs

Klara Gado

Norbert Nemeth

Aniko Miklos Nee Kovacs

Edit Nee Berenyi

Ivan Jakoczi

Gyorgyi Donath Vereczkey

Ildiko Ratz Nee Simonek

Gyorgyi Lax Kovanyi

Atti La Mandi

Sandor Tuboly

Gabor Nemei

Julianna Takacs Nee Bitai

Gyorgy Pirok

Jamos Gundel

Gyorgyi Nee Kovanyi

Piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions

The invention relates to a new process for the preparation of amlodipine besylate of the Formula ##STR1## Amlodipine besylate of the Formula I is a valuable known blood pressure decreasing antianginal agent. The advantage of the process of the present invention is that it can be carried out in a simple way with high yields and there is no need to isolate the amlodipine base.

Process for the preparation of a dihydropyridine derivative

This invention relates to new oxaindene derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The compounds according to the invention are characterized by the general formula (1) ##STR1## wherein R.sup.1 represents lower C.sub.1-4 alkyl, lower C.sub.1-4 alkoxy or lower C.sub.3-6 cycloalkyl,

Oxaindene derivatives and process for the preparation thereof

The invention relates to a process for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitro-phenyl)-pyridine-3,5-dicarbo xylate of the Formula I ##STR1## which comprises a) reacting a compound of the general Formula II ##STR2## (wherein n is 1 or 3; if n is 1, then R stands for a group of the Formula (a) ##STR3## and if n is 3, then R represents hydrogen) with methyl acetoacetate of the Formula III

1,4,Dihydro-pyridine intermediates

The invention is directed to processes for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarbox ylate by reacting 1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylene methanamie or 1-(2'-nitrophenyl)-N,N'-bis-(2'-nitrophenyl) methylene methanediamine with methyl acetoacetate in the presence of an amine compound or by reacting the monomeric or trimeric from of 2-nitrobenzaldimine with methyl acetoacetate.

Process for the preparation of 1,4-dihydro-pyridine derivatives

The invention relates to new dihydropyrimidothiazine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same and new intermediates useful in the preparation of the said dihydropyrimidothiazine derivatives.

Dihydropyrimidothiazine derivatives

The compounds of the general formula I ##STR1## and pharmaceutically acceptable acid addition salts and hydrates thereof possess useful immunostimulant properties and can be used in therapy. In the general Formula I

Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine

The invention relates to new quinoxaline-1,4-derivatives of the general formula (I) and biologically acceptable salts thereof, ##STR1## wherein Q is a hydrogen atom or a methyl group,

Quinoxaline-1,4-dioxide fodder suppliments

The invention relates to fodder concentrates, fodder additives and fodders having antimicrobial and/or weight-gain increasing effects which comprise as active ingredient a new compound of the general formula (I) ##STR1## wherein R represents a C.sub.1-20 alkyl, a C.sub.1-6 alkoxy group, an optionally substituted C.sub.6-10 aryl group, a phenyl-(C.sub.1-3 alkyl), a C.sub.3-7 cycloalkyl or a 5 or 6 membered heterocyclic group containing one or two nitrogen and/or oxygen and/or sulfur atom(s),

Pyridazino[4,5-b]quinoxaline-5,10-dioxide derivatives, a process for

The invention relates to fodder additives, fodder concentrates and fodders with weight gain increasing and fodder utilization improving effects, which contain as active agent a new compound of the general formula (I), ##STR1## The invention also relates to a process for the preparation of compounds having the general formula (I) by reacting a compound of the general formula (II), ##STR2## wherein Z is oxygen atom or represents two lower alkoxy groups and R.sup.1 is as defined above, with a compound of the general formula (III), ##STR3## wherein Q, A, B and n are as defined above, and, if desired, converting the resulting compound of the general formula (I) into another compound of the general formula (I) by well-known reactions. The compounds of the general formula (I) are new.

Methyl-quinoxaline-1,4-dioxide derivatives

The invention relates to novel quinoxaline-2-yl ethenyl ketones, their preparation and compositions containing them. The novel quinoxaline-2-yl ethenyl ketones of the general formula I ##STR1## wherein R.sub.1 represents an aryl group or a heterocyclic group comprising one or more nitrogen and/or oxygen and/or sulfur atoms wherein both the aryl and heterocyclic groups are optionally substituted by one or more identical or different substituents,

Quinoxaline-2-yl ethenyl ketones

Growing community of inventors

Budapest, Hungary

Daniel Bozsing