Janssen Sciences Ireland Unlimited Company

Bavarian Nordic A/s

Ichor Medical Systems, Inc.

Daniel Boden

Soumitra Roy

Jean-Marc Edmond Fernand Marie Neefs

Helen Horton

Dorien De Pooter

Robert M Bernard

Jerôme Hubertina Henricus Victor Custers

Andrew W Hannaman

Markus Kalla

Stephen A Morse

Adam Hartman

Roland Christian Zahn

Thomas David Cox

Oliver Ruck

Polynucleotides encoding hepatitis B virus (HBV) core antigen and polymerase antigen, and related combinations are described. Also described are vectors, such as DNA plasmids or viral vectors, expressing the HBV core and polymerase antigens, and immunogenic compositions containing the expression vectors. Methods of inducing an immune response against HBV or treating a HBV-induced disease, particularly in individuals having chronic HBV infection, using the immunogenic compositions are also described.

Hepatitis B virus (HBV) vaccines and uses thereof

Methods and apparatus for the reproducible, consistent and efficacious delivery of an HBV vaccine to a subject. The disclosure comprises apparatus for the controlled administration of the HBV vaccine through an orifice to the subject, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes.

Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines

The present invention concerns the use of a protein comprising at least a HIV-derived accessory protein tat (trans-activator of transcription) or any derivative thereof for the reactivation of latent human immunodeficiency virus (HIV) from cells present in a HIV-infected patient.

Use of a HIV derived accessory protein for the reactivation of latent HIV

Provided herein are Modified Vaccinia Ankara (MVA) vectors and adenovirus vectors encoding HBV antigens. Also provided are methods of enhancing an immune response in a human subject by utilizing the MVA and adenovirus vectors encoding HBV antigens in a prime/boost regimen to the enhance the immune response in the human subject.

Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV)

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San Mateo, CA, United States of America

Daniel Boden