Bracco International Bv

Battelle Memorial Institute

Sanofi-synthelabo

Sanofi

Assut S.a.

Imperial Chemical Industries Limited

Sintetica S.a.

Daniel Bichon

Michel Schneider

Philippe Bussat

Jerome Puginier

Eva Hybl-Sutherland

Eva Hybl

Vincenzo Proietto

Feng Yan

Didier Van Broeck

Patrick Gueule

Xavier Emonds-Alt

Marie-Bernadette Barrau

Francis Barth

Viviane Van Dorsselaer

Bernard Lamy

Frank Bolkenius

Pascal Grenier

Nadine Garcel

Murielle Rinaldi-Carmona

Christian Congy

Christian Guillot

Pascal Grenier, Deceased

Van T Nguyen

Xavier Edmonds-Alt

Nadine Gercel, Legal Representative

Maria-Bernadette Barrau

Nadine Garcel, Legal Representative

William Borloz

Andre E Myers

Jerone Puginier

The subject of the invention is compounds of formula (I): in which R-Rare as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.

Pyrrole derivatives, their preparation and their therapeutic application

Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.

Ultrasound contrast agents and methods of making and using them

One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.

Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof

Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.

Stable microbubbles suspensions injectable into living organisms

Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.

The invention relates to benzimidazole derivatives of general formula (I) Preparation process and therapeutic application.

Benzimidazole derivatives, preparation and therapeutic use thereof

Mixable combination for generating a suspension of stable microbubbles for ultrasonic imaging

Human NK3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them

A method for treating diseases which involve interaction of neurokinin B with NK,receptors in humans. The method comprises administering a therapeutically effective amount of a NK,antagonist compound having the formula:

Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools

Microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is both deformable and resilsient. These microballoons are used for ultrasonic echographic imaging of body organs.

Gas or air filled polymeric microballoons

Methods of making Ultrasonic contrast agents useful for echographic imaging body organs comprising a suspension of gas or air filled microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is both deformable and resilient are as described.

Method of making ultrasonic contrast agent

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Montpellier, France

Daniel Bichon