Protalix Ltd.

Daniel Bartfeld

Yoseph Shaaltiel

Gideon Baum

Sharon Hashmueli

Ayala Lewkowicz

Tal Ratz

Einat Mizrachi

Yehava Forester

A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.

Plant cell culture expressing human lysosomal proteins and uses thereof

Production of high mannose proteins in plant culture and therapeutic uses thereof

Human lysosomal proteins from plant cell culture

A system and method for production of antibodies in plant cell culture, which results in highly functional antibodies, produced with a high level of expression efficiency. The present invention also encompasses host cells, vectors and methods for mass production of full size assembled immunoglobulins.

System and method for production of antibodies in plant cell culture

Growing community of inventors

Moran-Doar-Na Bikat Beit HaKerem, Israel

Daniel Bartfeld