Elc Management LLC

Applied Genetics Incorporated

Applied Genetics Incorporated Dermatics

The University of Texas System

Isp Investments Inc.

Mironova Innovations, LLC

Daniel B Yarosh

Nadine A Pernodet

Yoko Niki

Edward Pelle

David A Brown

Kelly Dong

Mary S Matsui

Masaki Yoshida

Masamitsu Ichihashi

Hideya Ando

Donald Collins

Dawn Layman

Nouha Domloge

Jean-Marie Botto

Thomas Mammone

Lieve Declercq

Isabelle Imbert

Joel Mantelin

Anne B Brown

Frédérique Portolan

Jan Trampota

Donald F Collins

Margaret L Kripke

Naoaki Saito

Leonard F Estis

Eliyahu Kraus

Nevena Jurukovska-Karaman

Matthew T Canning

Nadine A Perdonet

Provided herein are methods and compositions for maintaining and/or increasing vitamin C in a cell or organism. The methods and compositions are based, in part, on the synergistic effect of ergothioneine, or a derivative thereof, on vitamin C levels in cells or organisms.

Ergothioneine compositions and methods for maintaining and/or increasing vitamin C levels in cells and organisms

A watery lotion composition for topical application to skin comprising at least one extract from the fermentation of the microorganism, at least one extract from the fermentation of the microorganism, and mineral water having at least 250 ppm of total mineral dissolved solids and a method for improving the efficacy of a watery lotion and/or a second skin care product by layering the products on the skin.

Watery lotion skin care compositions and methods

A skin care composition for stimulating selective catabolysis in cells of keratin surfaces comprising at least one autophagy activator and at least one proteasome activator, and a method for improving selective catabolysis in cells of keratin surfaces by treating with the composition.

Method or improving selective catabolysis in cells of keratin surfaces

The present invention relates to the cosmetic use of a combination of a hydrolysed rice extract and a grapeseed extract as an active agent to protect cutaneous cells from pollution. The present invention relates also to a cosmetic method of treatment for protecting skin epidermal cells from atmospheric pollution comprising applying on the skin area to be treated a composition comprising a combination of a hydrolysed rice extract and a grapeseed extract.

Method of cosmetic treatment to protect the skin from pollution and improve skin regeneration

Method and compositions for improving selective catabolysis in cells of keratin surfaces

A composition for treating keratin surfaces to stimulate selective catabolysis and improve cellular viability comprising at least one autophagy activator and at least one DNA repair enzyme, and a method for improving selective catabolysis and cellular viability by treating with the composition.

Method and compositions for improving selective catabolysis and viability in cells of keratin surfaces

A method for increasing cellular viability in cells of keratin surfaces after exposure to UV light and/or detoxifying cells of debris that impedes healthy metabolic function by topically applying to the keratin surface a composition containing at least one autophagy activator and at least one DNA repair enzyme and a method for making a topical composition comprising the steps of (a) identifying an ingredient that activates cellular autophagy in keratinocyte cultures in vitro, and (b) formulating the ingredient into a topical composition in combination with at least one DNA repair enzyme.

Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: or having the structure: as defined herein.

Skin lightening compositions

Compositions and methods for modulating melanogenesis by modifying tyrosinase palmitoylation are provided.

Modulation of melanogenesis by modification of tyrosinase by palmitoylation

Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure:  

Compositions comprising ergothioneine and a trimethylamine absorber are provided. Also provided are methods for preventing, reducing or minimizing the fishy, amine odor, due to trimethylamine, that is associated with the processing and/or storage of a preparation containing ergothioneine, by combining with the ergothioneine, during processing or prior to storage, a trimethylamine absorber in an amount sufficient to prevent the detection of any trimethylamine odor by the human nose. A method is further provided for ameliorating the methylamine odor associated with an aqueous ergothioneine-containing preparation after it has developed a fishy trimethylamine odor.

Preservation of ergothioneine

Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure:  as defined herein.

Recombinant forms of DNA sequences for CPD glycosylases, including the bacteriophage T4 gene denV, are described that are capable of expression at high levels. Active CPD glycosylases can be recovered from inclusion bodies resulting from the high expression using, for example, a homogenization process which employs stream mixing, and the active proteins can be used in, for example, topical formulations for treatment of photosensitive diseases. Stream mixing can also be used to solubilize inclusion bodies containing proteins other than CPD glycosylases.

Production of CPD glycosylases

Compositions and methods are provided for reversing and/or inhibiting inflammation, e.g., by inhibiting prostaglandin and/or COX-2 production, using one or more indolequinazoline alkaloids, preferably in combination with butylated hydroxytoluene. The preferred indolequinazoline alkaloids are rutaecarpine, evodiamine, and dehydroevodiamine, which are naturally found in unpurified form in the traditional Chinese medicine Wu Chu Yu made from the fruit of the herb,

Growing community of inventors

Merrick, NY, United States of America

Daniel B Yarosh