Other

International Medical Technologies Corporation

Daniel B Rubinstein

Alan I Rubinstein

A bone marrow biopsy needle provided with blades which cut and retain a biopsy core. In one embodiment, the cutting blades of the needle are hinged at the distal end of the needle and are mechanically coupled to an actuator at the proximal end of the needle. The needle is preferably formed with inner and outer walls to provide a space therebetween for the mechanical coupling. The cutting blades are retained in a dead space against the outer wall of the needle when the needle is open. In lieu of a hinged arrangement, the outer wall of the needle may be tapered at its distal end so that the blades are forced together when they are pushed forward. In another embodiment, the cutting blades are pre-curved inward, but are retained against the inner surface of the needle wall until pushed forward. In yet another embodiment, the distal ends of the cutting blades rest within a curved circumferential recess provided in the needle wall, and, when pushed forward, move together to cut and retain the biopsy core.

Bone marrow biopsy needle with cutting and/or retaining device at distal

A method of producing a vaccine comprising providing a quantity of the disease-causing entity, treating the quantity to remove or disrupt a majority of the nucleic acid present in the quantity sufficient to render the quantity non-infective while maintaining the structure of the proteins and glycoproteins on the surface of the entity to render the vaccine protective. A method of producing a vaccine to human pathogenic retroviruses comprising the steps of partially solubilizing a quantity of the virus to produce a suspension, adding a proteinase to the suspension to release viral nucleic acids from the viral coat proteins, treating the suspension to disrupt or remove sufficient viral nucleic acids to render the suspension substantially or completely non-infective and verifying the sufficient disruption or removal of viral nucleic acids from the suspension.

Non-infective vaccines

A bone marrow biopsy needle provided with blades which cut and retain a biopsy core. In one embodiment, the blades of the needle are hinged. In a further embodiment, the cutting blades are provided at the end of an inner tube which travels within an outer tube. In one embodiment, the outer tube is tapered at its distal end to push the blades together. In another embodiment, the cutting blade is pre-curved inward. In yet another embodiment, the distal ends of the cutting blades rest within a curved circumferential recess provided in the needle wall, and, when pushed forward, come together to cut and retain the biopsy core.

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Brookline, MA, United States of America

Daniel B Rubinstein