American Cyanamid Company

Daniel B Moran

Jay Donald Albright

John W Hanifin, Jr

George Rodger Allen, Jr

Yang-I Lin

Phaik-Eng Sum

Joseph P Joseph

Carl B Ziegler

Dennis W Powell

Carl B Ziegler, Jr

John P Dusza

7-(substituted)piperazinyl-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylic acids, the pharmacologically acceptable salts thereof, compositions containing them, processes and intermediates for producing them, and methods of using them to treat bacterial infections in warm-blooded animals.

Piperazine derivatives

Novel substituted quinolinecarboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkaline earth metal or lower alkyl; R.sub.2 is hydrogen, benzyl or alkyl (C.sub.1 -C.sub.3); X is hydrogen or fluoro; which have antibacterial activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to treat bacterial infections in animals.

8-fluoro and 7, 8,

7-(substituted)piperaziny

Novel substituted quinolinecarboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkaline earth metal or lower alkyl; R.sub.2 is hydrogen, benzyl or alkyl(C.sub.1 -C.sub.3); X is hydrogen or fluoro; which have antibacterial activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to treat bacterial infections in animals.

8-fluoro and

This invention concerns novel imidazo[1,2-b]-pyridazines and their use as agents for treating anxiety.

Imidazo[1,2-b]pyridazines

This disclosure describes novel substituted 1,2,4-triazolo[4,3-a]pyridines which possess anxioltic activity.

(Pyridinyl)-1,2,4-triazolo[4,3-a]pyridines

Substituted phenyl-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-ones, useful as anti-asthma agents.

Substituted phenyl-1,2,4-triazolo[2,3-b]pyridazin-3(2H)ones as

This disclosure describes novel [4R]-3-(.omega.-aroylpropionyl)-4-thiazolidinecarboxylic acids and esters and the cationic salts thereof which are useful as hypotensive agents in mammals.

[4R]-3-(.omega.-Aroylpropionyl)-4-thiazolidinecarboxylic acids and esters

A method of treating asthma in a warm-blooded animal using the compound 6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one.

Method of treating asthma

This disclosure describes novel 6- and 8-heteroaryl and substituted 6- and 8-heteroaryl-1,2,4-triazolo[4,3-b]-pyridazines and their use as agents for treating anxiety.

6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines

This disclosure describes novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines and their use as anxiolytic agents.

Novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines

This disclosure describes novel substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines useful as anxiolytic agents.

6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating

This disclosure describes compositions of matter useful as anxiolytic agents and the method of meliorating anxiety in mammals therewith; the active ingredients of said compositions of matter being certain substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines or the pharmacologically acceptable acid-addition salts thereof.

Method for treating anxiety in mammals

This disclosure describes novel substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines useful as hypotensive agents.

6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents

This disclosure describes novel alkyl 3-[6-(aryl)-3-pyridazinyl]-carbazates useful as hypotensive agents in mammals. SP

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Suffern, NY, United States of America

Daniel B Moran