Bristol-myers Squibb Compnay

Daniel B Davison

Brian A Dougherty

Ying-Kai Wang

Mengping Liu

Matthew D Healy

Charles E Mazzucco

Trina Maurice

John N Feder

Liana M Lee

Karl-Heinz Ott

The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.

Essential fungal polypeptide, CaYDR341c, and methods of use thereof

The presnt invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.

Essential fungal polynucleotides, polypeptides, and methods of use

Essential fungal CaYLR100w polypeptides, and methods of use

The present invention describes a novel human protein kinase related to citron kinase, and its encoding polynucleotide. Also described are expression vectors, host cells, antisense molecules, and antibodies associated with the protein kinase polynucleotide and/or polypeptide of this invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders or diseases associated with abnormal biological activity of the protein kinase are described, as are methods for screening for modulators, e.g., agonists or antagonists, of the protein kinase activity and/or function.

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Morrisville, PA, United States of America

Daniel B Davison