Abbott Laboratories Corporation

Daniel Ambrose Dunnigan

Martin Winn

Jaroslav Kyncl

Peter Hadley Jones

Adolph Oscar Geiszler

James Brooks Holland

Jerry R Martin

John S Tadanier

Leslie A Freiberg

Peter Handley Jones

Novel fortimicin antibiotics represented by the formula ##STR1## wherein R.sub.1 is loweralkyl, R.sub.2 is hydrogen or loweralkyl and R.sub.3 is selected from the group consisting of hydrogen, acyl, hydroxyacyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl or an aminoacid residue, loweralkyl, hydroxyloweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl; and the pharmaceutically acceptable salts thereof, intermediates useful in their preparation, compositions employing the compounds and methods of using the compounds.

6'N-Alkyl- and 6',6'-di-N-alkyl derivatives of fortimicins A and B

It has been found that dialkanoylacetones can be reduced to the corresponding glycerols by a rapid process using ruthenium on an inert support as the hydrogenation catalyst.

Process for preparing 1,3-diacyl glycerols

Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyquinazo line, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

Antihypertensive agents

Covers a compound selected from the group consisting of a member of the formula: ##STR1## wherein R.sub.1 is a radial selected from the group consisting of higher branched or straight chain alkyl and cycloalkyl radicals wherein said R.sub.1 radical contains at least six carbon atoms, R.sub.2 is a radical selected from the group consisting of hydrogen, loweralkyl and loweralkanol radicals, wherein said R.sub.2 radical contains 1 - 3 carbon atoms, and R.sub.3 is methoxy; and nontoxic pharmaceutically acceptable acid addition salts thereof. Also covers the use of said compound as a local anesthetic and pharmaceutical compositions comprising said above compounds as the active ingredient.

Aminotetralins and use in inducing anesthesia

Covers a compound selected from the group consisting of a member of the formula: ##STR1## where R.sub.1 is a radical selected from the group consisting of higher branched or straight chain alkyl and cycloalkyl radicals wherein said R.sub.1 radical contains at least six carbon atoms, R.sub.2 is a radical selected from the group consisting of hydrogen, loweralkyl and loweralkanol radicals, wherein said R.sub.2 radical contains 1-3 carbon atoms, and R.sub.3 is methoxy; and nontoxic pharmaceutically acceptable acid addition salts thereof. Also covers the use of said compound as a local anesthetic and pharmaceutical compositions comprising said above compounds as the active ingredient.

A two-step preparation of 3-arylpropyl chloride from the corresponding 2-chloropropiophenone by hydrogenation using two specific catalysts in series.

Manufacture of 3-arylpropyl chloride

Described are the compounds 2[4(tetrahydro-2-furoyl)-hexahydro-1,4-diazepinyl-1]-4-amino-6,7-dimethoxy quinazoline and pharmaceutically acceptable acid addition salts thereof. The compounds are useful as antihypertensive agents.

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Winthrop Harbor, IL, United States of America

Daniel Ambrose Dunnigan