Columbia University

Daniel Alexandre Chenet

James Hone

Samuel Jonas Wind

Ruben L Gonzalez, Jr

Matteo Palma

Colin Kinz-Thompson

Alexander Alexeevich Godarenko

The disclosed subject matter provides a nanoaperture having a bottom surface and a side wall comprising gold. A surface of the side wall is passivated with a first functional molecule comprising polyethylene glycol. The bottom surface of the nanoaperture can be functionalized with at least one second molecule comprising polyethylene glycol, for example, a silane-PEG molecule. The second molecule can further include a moiety, such as biotin, which is capable of binding a target biomolecule, which in turn can bind to a biomolecule of interest for single molecule fluorescence imaging analysis. Fabrication techniques of the nanoaperture are also provided.

Growing community of inventors

New York, NY, United States of America

Daniel Alexandre Chenet