The United States of America, as Represented by the Secretary, Department of Health and Human Services

Wake Forest University

Daniel A Sweeney

Mark Thomas Gladwin

S Bruce King

Daniel B Kim-Shapiro

Provided herein are methods of treating hemolysis by administering an active compound in an amount sufficient to treat said hemolysis. It has been found that nitroxyl donors or similar compounds preferentially react with cell-free OxyHb, as compared to OxyHb encapsulated in a red blood cell, and reacts with MetHb to form iron-nitrosyl Hb or nitrite bound MetHb. It has also been found that such compounds reduce cell-free Hb and hemolysis. Active compounds are also contemplated for use in combination therapies, for example, in combination with the administration of red blood cells and/or an agent that promotes hematopoiesis, or in combination with the administration of a nitric oxide donor.

Growing community of inventors

Laurel, MD, United States of America

Daniel A Sweeney