Allied Bioscience, Inc.

Taro Pharmaceutical Industries Limited

Taro Pharmaceuticals North America, Inc.

Other

Taro Pharmaceuticals U.s.a., Inc.

Taro Pharmaceuticals Industries

Taro Pharamaceutical Industries Ltd.

Daniel A Moros

Craig Grossman

Avraham Yacobi

Gavri Grossman

Barrie Levitt

Jie Fang

Howard Rutman

Daniella Gutman

Satish Asotra

Shen Gao

Parham Asgari

Maha El-Sayed

Misagh Alipour

Subhas Kundu

Sandhya Goyal

Michael M Friedman

Yechiel Golander

Maya Barder

Mohammed S Safadi

Theophilus Van Den Heuvel

Gavri Grossmann

Maxine Moldenhauer

Maxine G Moldenhauer

Aqueous antimicrobial coating compositions are disclosed comprising at least one organosilane homopolymer, present as a distribution of polymer chain lengths, and optionally at least one amine. A method of preparing an antimicrobial coating comprises coating a surface with the aqueous antimicrobial coating composition and allowing the composition to dry into a film that exhibits residual antimicrobial efficacy against microorganisms even after mechanical abrasion of the coating. The organosilane homopolymer may comprise only 3-aminopropylsilanetriol homopolymer, mixtures of 3-aminopropylsilanetriol homopolymer, 3-chloropropylsilanetriol homopolymer and 3-(trihydroxysilyl)propyl dimethyloctadecyl ammonium chloride homopolymer, or any one of various unique organosilane homopolymers having multiple amine functionality.

Antimicrobial coatings comprising organosilane homopolymers

The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (RO)Si&#x2014;R&#x2014;Z, an organic amine RRRN, a titanium (IV) species, a 1,2-diol, an &#x3b1;-hydroxy acid, &#x3b2;-hydroxy acid, and an organosilane grafted parylene polymer, wherein Ris H, alkyl, substituted alkyl, aryl or substituted aryl, Ris a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R, R, and Rare independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

Antimicrobial coatings for medical implements and medical devices

Antimicrobial coating compositions are used to form dried residual antimicrobial coatings on medical dressings including gauze, bandages, gowns and dry wipers. Antimicrobial coating compositions comprise at least one of an organosilane (RO)Si&#x2014;R&#x2014;Z, an organic amine RRRN a titanium (IV) species, a 1,2-diol, an &#x3b1;-hydroxy acid, a &#x3b2;-hydroxy acid, and an organosilane grafted parylene polymer, wherein Ris H, alkyl, substituted alkyl, aryl or substituted aryl, Ris a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent and R, R, and Rare independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

Antimicrobial coatings for medical dressings and dry antimicrobial medical dressings therefrom

The present disclosure provides antimicrobial coatings on a surface comprising a reactive silanol and triethanolamine. In various examples the reactive silane is 3-chloropropylsilane triol. The coating is capable of reducing the number of Murine norovirus andinoculated on the dried coating. In various examples, the coating further comprises a mixture of peroxotitanium acid and peroxo-modified anatase sol. The compositions may be electrostatically sprayed on the surface, and in certain examples, a mixture of silanol and triethanolamine is spray-coated on the surface followed by an aqueous mixture of peroxotitanium acid and peroxo-modified anatase sol.

Antimicrobial coatings capable of reducing the number of murine norovirus inoculated thereon

A method of coating a surface with an antimicrobial coating comprises spray-coating a mixture of 3-aminopropylsilane triol and triethanolamine on the surface. The coating is capable of reducing the number ofandinoculated on the dried coating. In various examples, the method further comprises the step of spray-coating a mixture of peroxotitanium acid and peroxo-modified anatase sol on the surface. The compositions may be electrostatically sprayed on the surface, and in certain examples, a mixture of silanol and triethanolamine is spray-coated on the surface followed by an aqueous mixture of peroxotitanium acid and peroxo-modified anatase sol.

Methods of coating a surface with an antimicrobial coating capable of reducing the number of murine norovirus inoculated thereon

A method of preparing an antimicrobial coating comprises coating a surface with an aqueous mixture of 3-(trihydroxysilyl)propyl dimethyloctadecyl ammonium chloride, 3-chloropropyltrimethoxysilane, and triethanolamine and then coating the surface with an aqueous titanyl sol-gel solution comprising an aqueous mixture of peroxotitanium acid and peroxo-modified anatase sol overtop of the silane to form the antimicrobial coating. The antimicrobial coating exhibits residual antimicrobial efficacy againstandafter water rinsing or after abrasion. The use of 3-chloropropyltrimethoxysilane was found to improve storage stability of the quaternary silane composition and the durability of the antimicrobial coating.

Antimicrobial coatings comprising quaternary silanes

An anti-microbial coating formulation consisting essentially of triethanolamine and a silane.

Methods of preparing reactive mixtures of silanes and triethanolamine and polymers therefrom

Methods of preparing self-decontaminating surfaces using reactive silanes, triethanolamine and titanium anatase sol

Antimicrobial coatings formed from mixtures of silanes and amines

The invention relates to an antimicrobial coating composition formed by admixing choline bitartrate or choline chloride, an aminopropyltrialkoxysilane and water. This coating composition is preferably sprayed onto a surface and allowed to dry. Preferably the surface is a stainless steel surface. The coating reduces the amount ofon the surface of the substrate.

Synergistic combinations of choline and reactive silanes in antimicrobial coatings

Anti-microbial coating and method to form same

A polymeric material formed by reacting aminopolyol having a structure: wherein R4 is selected from the group consisting of &#x2014;H and &#x2014;CH&#x2014;CH&#x2014;OH; and an organosilane, wherein said organosilane has a structure: 

Composition and method to form a self decontaminating surface

The present invention is directed to improved liquid antibiotic formulations. In some embodiments, the present invention is directed to a composition comprising an antibiotic in a liquid comprising triglycerides, wherein the composition has less than about 5% water (w/v).

Stabilizing compositions for antibiotics and methods of use

A method of treating movement disorders comprises administering to a human or animal subject in need of treatment a therapeutically effective amount of at least one compound according to the following formula: wherein Rand Rare each independently selected from the group consisting of lower alkyl, phenyl and lower alkyl substituted phenyl, and Rand Rare each independently either a hydrogen atom or a radical of the formula wherein Rand Rare each independently selected from the group consisting of H, lower alkyl, phenyl and lower alkyl substituted phenyl, its pharmaceutically acceptable salts, prodrugs or metabolites thereof.

Method of treating movement disorders using barbituric acid derivatives

Growing community of inventors

Larchmont, NY, United States of America

Daniel A Moros