Salvia Bioelectronics B.v.

Salvia Bioelectronic B.v.

Daniël Schobben

Hubert Martens

Koen Weijand

Maartje Van Der Zalm

Stephen Mark Gee

Mailys Guillard

Conventional devices deliver a degree of electrical charge into biological tissues; to satisfy regulatory and safety concerns, measures are taken to maintain a zero-charge residual at the stimulation site. Disclosed herein is a method of controlling electrical energy provided by a stimulation device to one or stimulation electrodes comprised in the device, the device including: a first stimulation electrode; a pulse energy controller for transferring electrical energy as one or more electrical stimulation pulses to the first stimulation electrode; the pulse energy controller further including two or more stimulation energy supplies for each supplying electrical energy substantially concurrently to the first stimulation electrode as a first pulse; and each supplying electrical energy separately to the first stimulation electrode as a second pulse. A simpler, more accurate and less-expensive control of stimulation may be provided by considering each energy supply as an energy building block, which may be selected as required.

Method of operating an electrical stimulation device with two or more stimulation energy supplies, and a stimulating device

Typically, stimulation therapy is provided using one or more implanted stimulation electrodes. Anatomy and treatment protocols can vary greatly—it is therefore advantageous to provide a highly configurable stimulation system. A tissue stimulation system is provided including an implantable end and a stimulation energy source, the implantable end including: an elongated substrate; one or more stimulation electrodes; and one or more proximal return electrodes; the stimulation energy source including: one or more distal return electrodes, disposed distantly from the one or more stimulation electrodes; and a pulse energy controller including a ratio controller, wherein: the proximal return electrodes and the distal return electrodes are configured as an electrical return for the stimulation electrodes; the ratio controller modifying the electrical potential and/or current ratio of the first part to the second part. A substantially transverse electric field may be provided. In addition, a ratio controller may also be provided.

Tissue stimulation device with distal and proximal return electrode

A mismatch in curvature of an electrode lead section may create unexpected and/or unpredictable electrical resistance with underlying tissue. In addition, repeated movement of the relevant areas of the body may even worsen the mismatch. Implants for electrical stimulation require low electrical resistance conductors for stimulation electrodes, return electrodes and interconnections which conventionally use metal for wires and contacts. These conductors reduce the flexibility, and the problem becomes worse as the number of electrodes increases. An implantable stimulation device is provided with an elongated substrate, one or more interconnections, a flexible electrode with two portions, separated by one or more bending interruptions, wherein the first portion and second portion are in direct electrical connection through the one or more interconnections. The electrode portions on opposite sides of the bending points are electrically connected allowing the mechanical bending and the electrical connections to be optimized separately.

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Eindhoven, Netherlands

Daniël Schobben