University of Pennsylvania

Daneil Malamud

Haim H Bau

Michael G Mauk

Changchun Liu

William R Abrams

Eran Geva

Xianbo Ceiu

Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium&#x2014;such as a lateral flow strip&#x2014;where the user may label and detect the nucleic acids.

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Daneil Malamud