Yale University

Biogen Idec Ma Inc.

Biogen, Incorporated

Dane S Worley

R Blake Pepinsky

Catherine A Hession

Stephen M Strittmatter

Michele Sanicola-Nadel

Richard L Cate

Daniel H S Lee

Dinah W Y Sah

Jane K Relton

Weiwei Li

Sylvia A Rabacchi

Dinah Y W Sah

Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.

Nogo receptor antagonists

Nucleotide and amino acid sequences are provided for compounds which promote tissue growth, as well as methods for modulating tissue growth, for imaging tissues and organs, and for treating patients.

Antibodies to Ret and RetL3

Nucleotide and amino acid sequences are provided for compounds which promote tissue growth, as well as methods for modulating tissue growth, for imaging tissues and organs, and for treating patients. Isolated nucleic acid and amino acid sequences for Ret ligands are disclosed. Ret ligands encoded by the isolated nucleic acid sequences of the invention have a hydrophobic N-terminal signal sequence, a hydrophobic C-terminal sequence and a phosphatidylinositol glycan linkage motif. Vectors and host cells that include Ret ligands encoded by the isolated nucleic acid sequences of the invention are also disclosed.

Ret ligand (RetL) for stimulating neutral and renal growth

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Somerville, MA, United States of America

Dane S Worley