Bristol-myers Squibb Compnay

Bristol-myers Squibb

Dane M Springer

Joanne J Bronson

Yasutsugu Ueda

Stanley V D'Andrea

John D Matiskella

Jason T Goodrich

Oak K Kim

Peter F Misco

John A Wichtowski

Bing Y Luh

Shelley E Hoeft

B Narasimhulu Naidu

Lawrence B Snyder

Alicia Regueiro-Ren

Thomas W Hudyma

Xiaofan Zheng

Muzammil M Mansuri

Margaret E Sorenson

Timothy P Connolly

Yunhui Zhang

Zhaoxing Meng

Roman Z Sterzycki

Katharine M Greene

Bing-Yu Luh

The present invention provides compounds of formula Ihaving potent antibiotic activity, including activity towards Gram-positive bacteria and mycobacteria.

O-derivatized nocathiacin derivatives

Isoxazolinone antibacterial agents

Provided by the present invention are cephem derivatives represented by the general formula

Bis quaternary MRSA cephem derivatives

Novel cephem derivatives represented by the general formula ##STR1## in which the Acyl substituent is a group of the formula ##STR2## wherein Ar is a lipophilic optionally substituted phenyl, naphthyl or pyridyl group; R.sup.1 represents either the residue of a heterocyclic amino acid or a C.sub.2 -C.sub.10 alkyl group substituted by both a carboxyl group and a group of the formula --NR.sup.9 R.sup.10 or ##STR3## in which R.sup.9 and R.sup.10 are each independently hydrogen or C.sub.1 -C.sub.6 alkyl, said C.sub.2 -C.sub.10 alkyl group being optionally interrupted by one or more nitrogen atoms or carbonyl groups, and R.sup.2 and R.sup.3 are each independently hydrogen, alkyl or aminoalkyl are gram-positive antibacterial agents, especially useful in the treatment of diseases caused by methicillin-resistant Staphylococcus aureus (also referred to below as MRSA or methicillin-resistant S. aureus).

Substituted 4-thio pyridones

Cephalosporin derviatives

Certain novel biaryl compounds are effective phospholipase A.sub.2 (PLA.sub.2) inhibitors.

Biaryl phospholipase A.sub.2 inhibitors

Growing community of inventors

North Haven, CT, United States of America

Dane M Springer