Colgate Palmolive Company

Brigham Young University

Dandan Chen

Harsh Mahendra Trivedi

James G Masters

Michael Prencipe

Gregory Szewczyk

Ying Yang

Robert D'Ambrogio

Stanislav Jaracz

Paul Thomson

Laurence Du-Thumm

Ammanuel Mehreteab

Zhigang Hao

Peter R Hilliard

Joe Vazquez

Carlo Daep

Yun Xu

Shao Peng Xu

Yuyan Zeng

Camille Zenobia

Jeffrey S Mclean

Wei Song

Gregory Szewzyk

Guangxin Lin

Richard P Darveau

James Gerard Masters

Jr Peter R Hilliard

Hailiang Lu

Provided herein is an oral care composition comprising a basic amino acid or a salt thereof in an amount of from 0.001 weight % to 0.08 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.

Oral care composition

Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. Some methods are based on IL-1β levels in the individual's GCF at the site of inflammation. Some methods are based on MIF and/or CCL-1 levels in the individual's GCF in healthy tissue distant from the site of inflammation. Some disclosed methods are based on temporal differences in IL-8, IL-6 and/or TNFα levels in the individual's GCF in healthy tissue distant from the site of inflammation during the development of plaque induced inflammation. Methods of treating an individual who has gingivitis and methods of preventing gingivitis are also provided. The treatment and prevention methods comprise determining if individual is a slow gingivitis responder or a high gingivitis responder and applying oral care compositions to the individual's oral cavity.

Biomarker of gingivitis diagnosis and treatment

Methods of increasing sIgA and mucin 5B levels in an individual's oral cavity are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase sIgA and mucin 5B levels in the individual's oral cavity, an oral care composition comprising: zinc phosphate, stannous fluoride and optionally, an organic acid buffer system.

Methods of inducing sIgA and mucin 5b in the oral cavity

This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.

Oral care compositions and methods of use

Aqueous oral compositions containing a cationic steroidal compound and a quaternary ammonium compound are suitable for treating conditions of the oral cavity.

Oral care compositions

A method of determining the effects of a test component on intracellular ROS levels. The method can be used in marketing or in screening for useful components in reducing ROS levels in cells adversely affected by increased ROS generation.

Method of measuring effects of components on cell reactive oxygen species production

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Bridgewater, NJ, United States of America

Dandan Chen