Centro De Ingenieria Genetica Y Biotecnologia

Danay Cibrian Vera

Diana Garcia Del Barco Herrera

Gerardo Enrique Guillen Nieto

Jorge Amador Berlanga Acosta

Sonia Gonzalez Blanco

Luis Saturnino Herrera Martinez

Jose Ignacio Fernandez Montequin

Raimundo Ubieta Gomez

Vivian Maria Saez Martinez

Gerardo Enrique Guillén Nieto

Ernesto Lopez Mola

Mariela Vazquez Castillo

Manuel Selman-Housein Sosa

Jorge Berlanga Acosta

José Suarez Alba

Vivian María SÁEZ MARTÍNEZ

Raimundo Ubieta GÓMEZ

Diana García Del Barco Herrera

José Ignacio Fernández Montequín

The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.

Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy

The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

Method for controlling fibrosis and other pathological deposits in tissues comprising administering a GHRP-6 composition

The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

Growing community of inventors

Ciudad de la Habana, Cuba

Danay Cibrian Vera