Bend Research, Inc.

Pfizer Corporation

Dana Marie Settell

Roderick Jack Ray

Ronald Arthur Beyerinck

Dan E Dobry

Ken R Spence

Heather L M Deibele

Heather L M Diebele

Dwayne Thomas Friesen

Daniel Elmont Dobry

Heather Lynn Deibele

Kenny Ray Spence

Heather Lynn Melcher Deibele

Spray drying processes are used to form pharmaceutical compositions comprising a solid amorphous dispersion of a drug and a polymer.

Spray drying processes for forming solid amorphous dispersions of drugs and polymers

Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.

Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus

Homogeneous solid amorphous dispersions of drugs in concentration-enhancing polymers are formed in desirable larger particle sizes with minimal fines by using an atomizer and process conditions capable of producing droplets having an average diameter of at least 50 microns and a Dof at least 10 microns.

Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles

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Bend, OR, United States of America

Dana Marie Settell