University of California

Dana J Levine

Jeffrey R Long

Miguel I Gonzalez

Olsalazine (Holz), a prodrug of the anti-inflammatory 5-aminosalicylic acid, is used as a ligand to synthesize a suite of M(Holz) and M(olz) materials, where M is a dication (e.g. Mg, Ca, Sr, Fe, Co, Ni, Cu, Zn). A family of metal olsalazine coordination polymers, coordination solids, and metal organic frameworks are described, which include 1-, 2-, and 3-dimensional structures. The materials resist degradation at acidic pH and release olsalazine preferentially at neutral pH. The mesoporous M(olz) frameworks exhibit high surface areas with hexagonal pore apertures that are approximately 27 &#x212b; in diameter and contain coordinatively unsaturated metal sites. Biologically active molecules containing a Lewis-basic functional group can be grafted directly to the open metal sites of the frameworks. Dissolution of the frameworks under physiological conditions releases olsalazine (Holz) and the grafted molecules so that multiple therapeutic components can be delivered together at different rates.

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Bonita, CA, United States of America

Dana J Levine