Yeda Research and Develpment & Co. Ltd

Dana Elias

Irun R Cohen

Doron Markovits

Rivka Abulafia

Jana Bockova

Matityahu Fridkin

Meir Shinitzky

Novel peptides which are epitopes of the human 60 kDa heat shock protein (hsp60) may be used for the diagnosis and treatment of insulin-dependent diabetes mellitus (IDDM). Pharmaceutical compositions containing such peptides and kits for use in diagnosis of IDDM are also disclosed.

Peptides derived from human heat protein 60 for treatment of diabetes, compositions, methods and kits

Metabolizable lipid emulsions, such as Intralipid and Lipofundin, are excellent vehicles for peptide therapy of autoimmune diseases and of other TH1 T cell mediated diseases or conditions, as it promotes a TH1 to TH2 cytokine shift. Such emulsions may be used in conjunction with an antigen recognized by inflammatory T cells associated with the pathogenesis of a T cell mediated disease or condition for the therapeutic treatment of such

Preparations for the treatment of T cell mediated diseases

It has been discovered that treatment of an IDDM model with the p277 auto-antigen in a tolerogenic carrier induces a shift from a TH1 T cell response to a TH2 T cell response. The efficacy of proposed vaccines for any T cell mediated disease can be detected or monitored by measuring for such a TH1&rarr;TH2 T cell reponse shift.

Method for detecting or monitoring the effectiveness of treatment of T cell mediated diseases

A peptide having the structure of the p277 sequence of hsp60 in which one or both cysteine residues are replaced by valine residues and/or in which the Thr,residue is replaced by Lys, has substantially the same biological activity as p277 but with substantially improved stability. The novel p277 analogues may be used for every purpose that p277 can be used.

Peptide p277 analogs, and pharmaceutical compositions comprising them for treatment or diagnosis of diabetes

Peptides derived from human heat shock protein 60 for treatment of

Peptides and pharmaceutical compositions comprising them

A 65 KD heat shock protein, proteins cross-reactive therewith, antibodies thereto or T cells specific thereto can be used for detecting in humans the existence of, a tendency to develop, or the initiation of a process leading to insulin dependent diabetes mellitus. Antibodies to hsp65 can be used to detect the hsp65 molecule in blood or urine. The hsp65 molecule of any species, or any other substance immunologically cross-reactive therewith, when administered with a tolerogenic carrier, can be used for the prevention or treatment of IDDM prior to development of clinical symptoms thereof. T cells, active fragments thereof or the receptor peptide thereof can also be used for prevention or treatment of IDDM.

Diagnosis and treatment of insulin dependent diabetes mellitus using

A 65 KD heat shock protein, proteins cross-reactive therewith, or antibodies thereto can be used for detecting in humans the existence of, a tendency to develop, or the initiation of a process leading to insulin dependent diabetes mellitus. Antibodies to hsp65 can be used to detect the hsp65 molecule in blood or urine. The hsp65 molecule of any species, or any other substance immunologically cross-reactive therewith, when administered with a tolerogenic carrier, can be used for the prevention or treatment of IDDM prior to development of clinical symptoms thereof.

Growing community of inventors

Rehovot, Israel

Dana Elias