Wisconsin Alumni Research Foundation

Dana C Baiu

Jamey Paul Weichert

Mario Otto

Bryan P Bednarz

It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and Ris —N(CH). The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, Rincludes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, Rincludes a detection moiety, such as a fluorophore or a radioactive iodine isotope.

Phospholipid ether analogs for imaging and targeted treatment of pediatric solid tumors

It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and Ris &#x2014;N(CH). The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, Rincludes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, Rincludes a detection moiety, such as a fluorophore or a radioactive iodine isotope.

Growing community of inventors

Madison, WI, United States of America

Dana C Baiu