Technion Research & Development Foundation Ltd

Dana Atia-Glikin

Timor Baasov

Valery Belakhov

Jeyakumar Kandasamy

A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5″ position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein Ris selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

Aminoglycosides and uses thereof in treating genetic disorders

A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5&#x2033; position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein Ris selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

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Schania, Israel

Dana Atia-Glikin