The University of North Carolina at Chapel Hill

Florida State University Research Foundation, Inc.

Emory University

Dan Yan

Richard K Plemper

Jing Wan

H Shelton Earp, Iii

Douglas Kim Graham

Deborah Ann DeRyckere

The invention provides combinations comprising a MERTK inhibitor, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor and methods of use thereof, including methods of treating disorders such as cancer.

Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor

An RSV reporter strain that can be used for high-throughput drug discovery is disclosed. Also disclosed is a recombinant RSV vector that contains an RSV genome encoding the disclosed RSV reporter strain operably linked to an expression control sequence. Also disclosed is an infectious RSV virion produce by expression of the disclosed recombinant RSV vector in a host cell. Also disclosed is a recombinant nucleic acid that comprises an RSV F protein having an escape mutation operably linked to a heterologous expression control sequence. Also disclosed are methods of screening for antiviral agents using the disclosed RSV reporter strains.

Recombinant RSV reporter virus

Growing community of inventors

Lilburn, GA, United States of America

Dan Yan