Telefonaktiebolaget Lm Ericsson (publ)

Beijing Friendship Hospital, Capital Medical University

302 Military Hospital of China

Dan Yan

Yu Zhang

Ping Zhang

Wei Zhao

Zhancang Wang

Cheng Jin

Xiaohe Xiao

Jianglan Long

Aiting Wang

Bangwei Cao

Yongshen Ren

A use of baicalin in preparation of a drug for treating a tumor irresponsive to immune checkpoint inhibitors (ICIs)/undergoing hyperprogression is provided, where the non-response to ICIs/hyperprogression of the tumor is caused by excessive Foxp3Treg cells; the targeted tumor is one selected from the group consisting of melanoma, non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), liver cancer, colorectal cancer (CRC), urothelial bladder cancer, and pancreatic cancer; and the ICIs is one or a mixture of two or more selected from the group consisting of a PD-1 inhibitor, a PD-L1 inhibitor, and a CTLA-4 inhibitor. In the present disclosure, baicalin is used in combination with ICIs to inhibit a number of Foxp3Treg cells in a tumor to play an anti-tumor sensitization effect, which can effectively treat a variety of tumors irresponsive to ICIs/undergoing hyperprogression caused by excessive Foxp3Treg cells.

Use of baicalin in preparation of drug for treating tumor irresponsive to immune checkpoint inhibitors (ICIs)/undergoing hyperprogression

A power amplifier is disclosed for amplifying an input signal and providing an amplified signal to a load at a junction node. The power amplifier comprises a splitter network, a carrier amplifier path and a peaking amplifier path. The peaking amplifier path comprises a first impedance transformer coupled between a peaking output matching network and the junction node to enhance the off-state impedance of the peaking amplifier. The carrier amplifier path comprises a second impedance transformer coupled between a carrier output matching network and the junction node.

Power amplifier and radio frequency device comprising the same

A sterility test method includes: selecting strain and culture medium, preparing bacterial cultures, transcribing fingerprint characteristics in thermograms as indices to verify the characteristics, drawing the thermodynamic parameters of the thermogram, determining the positive judgment index and performing sterility test for the samples. A fully-enclosed bacteria collecting ampoule incubator includes bacteria collecting ampoule system, sample and liquid feeding system and peristalsis liquid discharge system. The sample and liquid feeding system is connected with the bacteria collecting ampoule system by the liquid intake tube; and the bacteria collecting ampoule system is connected with the peristalsis liquid discharge system by the liquid drainage tube. The invention is characterized by short inspection time, high sensitivity, high automation and accurate test results on microbial contamination. It can also provide the overall process curve on the growth conditions. Such curve is provided with relatively favorable fingerprint, which enables qualitative analysis on the microbial contamination conditions.

Sterility test method and totally enclosed bacterial ampoule incubator used by it

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Beijing, China

Dan Yan