Nankai University

Shenzhen Ying Biopharmaceutical Co., Ltd

Dan Wang

Li Gao Xiong

Zhen Xi

Wei Xu

Sheng Liu

Yuanyuan Mei

Lifang Sun

Zhenghua Wang

Juanjuan Bi

Ningning Wang

Zhaoxia Guo

Nasrullah

Disclosed are a cyclic dinucleotide prodrug molecule, a preparation method therefor and an application thereof relating to the field of pharmaceuticals. The cyclic dinucleotide prodrug molecule has a structure shown in formula I, II, or III, can freely cross cell membranes and release cyclic dinucleotide, and has high cell activity.

Cyclic dinucleotide prodrug molecule, preparation method therefor and application thereof

This disclosure provides a stress-responsive polypeptide sequence for fusion with a polypeptide to specifically induce stability of the fusion polypeptide under stress conditions, such as drought, high salt and high temperature, in plants. Also disclosed includes an expression vector for expressing a fusion polypeptide comprising the stress-responsive peptide in plants transformed therewith, and a method for generating a transgenic plant with enhanced tolerance to environmental stresses, comprising introducing into the transgenic plant a polynucleotide encoding a fusion polypeptide which comprises the stress-responsive peptide as disclosed and a plant anti-stress gene, such as the plant senescence-associated gene SSPP. A plant expressing the expression vector that have an enhanced stress tolerance, includingand soybean, is also provided.

Polypeptide and use thereof for improving stress tolerance in plants

Growing community of inventors

Tianjin, China

Dan Wang